骨肉瘤相关基因多态性的研究进展OACSTPCD
Research Progress on Gene Polymorphisms Related to Osteosarcoma
骨肉瘤好发于儿童及青少年,是一类恶性程度高、致残率致死率高的骨性原发恶性肿瘤,探索其发生发展和预后的生物标志物至关重要.全基因组关联研究发现基因多态性在骨肉瘤的发病机制中发挥重要作用.本研究通过分析肿瘤相关基因的单核苷酸多态性功能,为探索骨肉瘤可靠的生物标志物提供新思路.
Osteosarcoma,which primarily affects children and adolescents,is a highly malignant bone tumor with high rates of disability and mortality.Therefore,the exploration of biological markers related to its occurrence,development,and prognosis is crucial.Genome-wide association studies have revealed the vital role of genetic polymorphisms in the pathogenesis of osteosarcoma.This study aims to provide new insights into reliable biomarkers of osteosarcoma through the analysis of the functional single-nucleotide polymor-phisms of tumor-related genes.
张鹏;陈凯;黄玲玲;刘金燕;田文
450008 郑州,郑州大学附属肿瘤医院(河南省肿瘤医院)骨与软组织科||450001 郑州,郑州大学公共卫生学院450001 郑州,郑州大学公共卫生学院450008 郑州,郑州大学附属肿瘤医院(河南省肿瘤医院)骨与软组织科
临床医学
骨肉瘤易感性基因多态性生物标志物全基因组关联分析
OsteosarcomaSusceptibilitySingle nucleotide polymorphismsBiomarkersGenome-wide asso-ciation study
《肿瘤防治研究》 2024 (008)
625-629 / 5
Henan Province Science and Technology Research Projects(No.242102310351);Henan Province Medical Science and Technology Research Plan Key Project of Provincial and Ministerial Cooperation(No.SBGJ202302021) 河南省科技攻关项目(242102310351);河南省医学科技攻关计划省部共建重点项目(SBGJ202302021)
评论