血清标志物联合miRNA-let-7对胶质母细胞瘤化疗效果及预后的评估价值OACSTPCD
Evaluation Value of Serum Markers Combined with miRNA-let-7 in Chemotherapy Effect and Prognosis of Glioblastoma Multiforme
目的 分析miRNA-let-7联合血清标志物对多形性胶质母细胞瘤(GBM)患者化疗效果和预后的预测效果.方法 收集25例GBM患者临床资料.纳入同期20名健康志愿者作为对照组.收集患者空腹血清样本,通过实时定量PCR分析血清样本中let-7b、let-7d以及let-7e水平.结果 与对照组相比,GBM组患者外周血中let-7b(192.50±18.71 vs.98.13±11.68,t=6.42,P<0.0001)、let-7d(82.…查看全部>>
Objective To analyze the predictive effect of miRNA-let-7 combined with serum markers on the chemotherapy effect and prognosis of glioma(GBM)patients.Methods We collected the data of 25 patients with GBM.Twenty healthy volunteers were included as the control group.Fasting serum samples were collected.The levels of let-7b,let-7d,and let-7e in serum samples were analyzed by quantitative real-time PCR.Results Compared with the control group,the levels of let-7b…查看全部>>
赵洁;师秋霞;付强
830054 乌鲁木齐,新疆医科大学第一附属医院神经外一科830054 乌鲁木齐,新疆医科大学第一附属医院神经外一科830054 乌鲁木齐,新疆医科大学第一附属医院神经外一科
临床医学
miRNA-let-7多形性胶质母细胞瘤化疗预后治疗反应
miRNA-let-7Glioblastoma multiformeChemotherapyPrognosisTherapeutic response
《肿瘤防治研究》 2024 (8)
684-689,6
Open Project of Xinjiang Key Laboratory of Neurological Disease Research(No.XJDX 1711-2202) 新疆神经系统疾病研究重点实验室开放课题(XJDX 1711-2202)
评论