基于胃络理论探讨慢性胃炎"炎癌转化"的病机与防治OA北大核心CSTPCD

The " inflammation cancer transformation" in chronic gastritis is a complex process that involves multiple factors,stages,and mechanisms. As the disease progresses,morphological changes occur in the gastric mucosal gland orifices and capillary vessels,and pathologically,it is characterized by a reduction in the number of glands,structural disarray,or cellular atypia. In traditional Chinese medicine,the onset of chronic gastritis is believed to be related to external pathogenic factors invading the stomach or the internal generation of various pathogenic factors. The disease process is considered to progress from qi to blood,and from meridians to collaterals,which is in line with the theory of "prolonged disease invading collaterals". This article explores the pathogenesis,prevention,and treatment of the "inflammation cancer transformation" in chronic gastritis based on the theory of the stomach collaterals,summarizing the characteristics of the disease evolution as follows:the stomach collaterals are invaded by pathogenic factors,leading to disharmony of qi and collaterals;obstruction of the stomach collaterals,resulting in the internal production of turbid toxins;and deficiency of the stomach collaterals,leading to the loss of nourishment and masses. Clinically,the therapeutic methods include expelling pathogenic factors,regulating qi,and activating collaterals;resolving stasis and detoxifying to unblock collaterals;and replenishing deficiency and eliminating masses to nourish the collaterals,thereby ensuring the patency of the stomach collaterals and the nourishment of the stomach. Starting from the theory of the stomach collaterals and integrating modern scientific research,this article aims to provide theoretical reference and practical guidance for the differential diagnosis and dynamic comprehensive management of the "inflammation cancer transformation" in chronic gastritis.