北京中医药大学学报2024，Vol.47Issue(8)：1119-1125,7.DOI:10.3969/j.issn.1006-2157.2024.08.013
丹蛭降糖胶囊联合达格列净治疗2型糖尿病周围血管病变的临床研究
Clinical study on the combination of the Danzhi Jiangtang Capsule and dapagliflozin for type 2 diabetes mellitus with peripheral vascular disease
摘要
Abstract
Objective This study aimed to explore the effect of the combined Danzhi Jiangtang Capsule with dapagliflozin on the blood lipid profile and related inflammatory markers in patients with type 2 diabetes mellitus with peripheral vascular disease. Methods 72 patients with type 2 diabetes mellitus with peripheral vascular disease who met the inclusion criteria were admitted to the Department of Endocrinology,The First Affiliated Hospital of Anhui University of Chinese Medicine,from April 2021 to April 2023. The patients were assigned to the experimental group and the control group using the random number table method (36 cases in each group). The control group was treated with dapagliflozin in addition to standard treatment,while the experimental group received the Danzhi Jiangtang Capsule for 12 weeks. Clinical efficacy,glucose and lipid metabolism indicators,hypersensitive C-reactive protein (hs-CRP),body mass index (BMI) levels,and traditional Chinese medicine (TCM) syndrome scores were observed pre-and post-treatment.Results In post-treatment,the clinical efficacy was higher in the experimental group than in the control group. Significant reductions in fasting blood glucose (FPG),2 h postprandial glucose (2 hPG),triglycerides (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),hs-CRP,BMI,and increased high-density lipoprotein cholesterol (HDL-C) were observed. Scores for TCM syndrome and individual items also decreased (P<0.05). Comparisons within the groups for pre-and post-treatment showed reductions in FPG,2 hPG,TG,TC,LDL-C,hs-CRP,and an increase in HDL-C,along with a decrease in total scores of TCM syndrome (P<0.05). Conclusion The Danzhi Jiangtang Capsule combined with dapagliflozin in the treatment of type 2 diabetes mellitus with peripheral vascular disease can regulate the blood lipid profile,reduce inflammatory factors,and improve patient's symptoms. Integrated traditional Chinese and Western medicine treatment are more conducive to controlling the disease,and TCM can be used in clinical practice as a combination treatment.关键词
糖尿病周围血管病变/丹蛭降糖胶囊/血脂谱/超敏C反应蛋白/中医证候Key words
diabetes peripheral vascular disease/Danzhi Jiangtang Capsule/blood lipid profile/hypersensitive C-reactive protein/traditional Chinese medicine syndrome分类
医药卫生引用本文复制引用
刘剑,方朝晖,倪英群,赵进东,陆瑞敏,王奔,严瑜珊..丹蛭降糖胶囊联合达格列净治疗2型糖尿病周围血管病变的临床研究[J].北京中医药大学学报,2024,47(8):1119-1125,7.基金项目
国家自然科学基金项目(No.81774286,No.82274468) （No.81774286,No.82274468）
国家中医药管理局中医科技与创新能力提升项目 （）
安徽省高校协同创新项目(No.GXXT-2020-025) National Natural Science Foundation of China(Nos.81774286 and 82274468) （No.GXXT-2020-025）
