北京中医药大学学报2024，Vol.47Issue(8)：1145-1151,7.DOI:10.3969/j.issn.1006.1006-2157.2024.08.017
复方苁蓉益智胶囊治疗轻中度阿尔茨海默病患者的临床疗效研究
Clinical study of Compound Congrong Yizhi Capsule in treating mild to moderate Alzheimer's disease
摘要
Abstract
Objective We aimed to observe the clinical efficacy and safety of Compound Congrong Yizhi Capsule in subjects with mild to moderate Alzheimer's disease (AD). Methods A total of 65 subjects with mild to moderate AD who visited the Affiliated Hospital of Qingdao University and Xuanwu Hospital of Capital Medical University from February 2023 to February 2024 were selected and divided into the Compound Congrong Yizhi Capsule group (40 cases) and the Donepezil Hydrochloride group (25 cases) for a 6-month treatment. The primary outcome measures included the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog) score and Auditory Verbal Learning Test (AVLT) score. Secondary outcome measures included the Mini-Mental State Examination (MMSE),Activities of Daily Living (ADL),Rey-Osterrieth Complex Figure Test (ROCFT),Trail Making Test (TMT),Verbal Fluency Test (VFT),Symbol Digit Modalities Test (SDMT),Digital Span Test (DST),Clock Drawing Test (CDT),and Boston Naming Test (BNT) scores,as well as clinical biochemical indicators including blood lipids,blood glucose,liver and kidney function. Results Compared with the Donepezil Hydrochloride group after treatment,subjects in the Compound Congrong Yizhi Capsule group showed an increase in ADAS-Cog and AVLT-total scores,and a decrease in MMSE,Rey-Osterrieth Complex Figure Copy Test,and CDT scores (P<0.05). Additionally,there was an increase in alanine aminotransferase (ALT),blood urea nitrogen(BUN),and total bilirubin (TBIL) levels,and a decrease in indirect bilirubin (IBIL) levels (P<0.05).Conclusion Compound Congrong Yizhi Capsule exerts a regulatory effect on cognitive function in subjects with AD,especially in the cognitive domains of episodic memory and visual-spatial processing ability. It also improves certain clinical indicators such as ALT,BUN,TBIL,and IBIL. This suggests that the early intervention with Compound Congrong Yizhi Capsule in AD can effectively improve symptoms,delay disease progression,and fully embody the concept of traditional Chinese medicine's preventive approach to illness.关键词
复方苁蓉益智胶囊/轻中度阿尔茨海默病/认知功能/临床疗效/治未病Key words
Compound Congrong Yizhi Capsule/mild to moderate Alzheimer's disease/cognitive function/clinical efficacy/preventive treatment of disease分类
医药卫生引用本文复制引用
李孟媛,孙锦平,孙伟,张占军,李鹤..复方苁蓉益智胶囊治疗轻中度阿尔茨海默病患者的临床疗效研究[J].北京中医药大学学报,2024,47(8):1145-1151,7.基金项目
国家自然科学基金重点项目(No.82130118) （No.82130118）
科技部科技创新2030重大项目(No.2022ZD0211600) （No.2022ZD0211600）
中央级公益性科研院所基本科研业务费专项资金资助项目(No.Z0739) National Natural Science Foundation of China(No.82130118) （No.Z0739）
