磁共振成像2024，Vol.15Issue(7)：21-26,6.DOI:10.12015/issn.1674-8034.2024.07.004
一体化18F-FET PET/MR术前评估成人胶质瘤患者MGMT基因启动子甲基化状态
Preoperative assessment of MGMT gene promoter methylation status in adult high-grade glioma patients by integrated 18F-FET PET/MR
摘要
Abstract
Objective:To investigate the discriminative ability of integrated 18F-fluoroethyltyrosine (18F-FET) positron emission tomography (PET)/MR for O6-methylguanine DNA methyltransferase (MGMT) gene promoter methylation status in adult gliomas. Materials and Methods:A total of 16 patients with unbiopsied or untreated gliomas were retrospectively enrolled to complete integrated PET/MR scans,including 18F-FET PET,conventional MRI and intravoxel incoherent motion (IVIM) imaging. The volume of interest (VOI) segmentation of PET images was performed using target-background ratio (TBR)=1.6 as a threshold,and IVIM maps corresponding to tumor VOI and their parameters,apparent diffusion coefficient (ADC),true diffusion coefficient (D),pseudo diffusion coefficient (D ),perfusion fraction (f),distributed diffusion coefficient (DDC),and heterogeneity index (α),were obtained by rigid alignment,and the corresponding first-order gray-scale histogram features were obtained by feature extraction of each parameter using pyradiomics. The eigenvalues corresponding to each IVIM parameter map were calculated in relation to the 18F-FET PET parameters,and the ability of PET and IVIM parameters to discriminate MGMT promoter methylation was explored using between-group comparisons and receiver operating characteristic (ROC) curve analysis. Results:The two eigenvalues 90th percentile (r=0.526,P<0.05) and maximum (r=0.520,P<0.05) of IVIM-α were positively correlated with mean standard uptake value (SUVmean) of PET parameter;The differences between IVIM-α and SUVmean in the two groups of positive and negative MGMT promoter methylation status were statistically significant (P<0.05),and the positive group had significantly higher mean IVIM-α and SUVmean than the negative group. The area under the curve (AUC) of discrimination of the methylation status of the MGMT promoter by incorporating the mean IVIM-α value and SUVmean was 0.77. Conclusions:18F-FET PET and IVIM parameters based on integrated PET/MR can effectively predict MGMT promoter methylation status in gliomas.关键词
胶质瘤/O6-甲基鸟嘌呤-DNA甲基转移酶启动子甲基化/18F-氟乙基酪氨酸正电子发射断层成像/正电子发射断层成像/磁共振/体素内不相干运动/磁共振成像Key words
glioma/O6-methylguanine DNA methyltransferase gene/18F-Fluoroethyltyrosine positron emission tomography (18F-FET PET)/positron emission tomography/magnetic resonance (PET/MR)/intravoxel incoherent motion/magnetic resonance imaging分类
医药卫生引用本文复制引用
韩青青,霍力,李拓,林增萍,李恩慧,杨阳,刘家惠,邢浩,王裕,程欣..一体化18F-FET PET/MR术前评估成人胶质瘤患者MGMT基因启动子甲基化状态[J].磁共振成像,2024,15(7):21-26,6.基金项目
北京协和医院中央高水平医院临床科研专项(编号:2022-PUMCH-A-019)Peking Union Medical College Hospital Centralized High-level Hospital Clinical Research Special Project(No.2022-PUMCH-A-019). （编号:2022-PUMCH-A-019）
