磁共振成像2024，Vol.15Issue(7)：81-86,6.DOI:10.12015/issn.1674-8034.2024.07.014
合成MRI联合MUSE-DWI鉴别胶质瘤复发和治疗相关改变的应用研究
Application of synthetic MRI combined with MUSE-DWI to differentiate glioma progressive disease from treatment-related changes
摘要
Abstract
Objective:To assess the utility of synthetic MRI quantitative parameters and multiplexed sensitivity encoding diffusion weighted imaging (MUSE-DWI) in combination to differentiate glioma progressive disease (PD) from treatment-related change (TRC). Materials and Methods:In this study,we collected 45 patients who exhibited new enhancing lesions after surgery followed by completion of chemoradiation therapy from September 2020 to November 2022. The scan sequences included synthetic MRI,MUSE-DWI and contrast enhanced T1-weighted imaging (CE_T1WI). The patients were classified into two groups:PD group (n=26) and TRC group (n=19). The ROI is placed on each image to measure apparent diffusion coefficient (ADC),pre-contrast T1,T2 value (T1pre,T2pre) and post-contrast T1,T2 value (T1post,T2post). Quantitative parameters (T1pre,T2pre and T1post,T2post) and ADC were evaluated using Student's t-test or Mann-Whitney U test. We generated receiver operating characteristic (ROC) curves for each parameter and their combinations. Finally,we used the area under the ROC curve (AUC) to assess the performance of each parameter and their combinations. Results:(1) The T1pre value in the PD group were significantly higher than the TRC group (P<0.05). The values of T1post and ADC in the PD group were significantly lower than the TRC group (all P<0.05). There was no statistical difference in T2pre,T2post value (P>0.05). (2) ADC diagnostic performance was highest when using single parameter analysis (AUC=0.878),followed by T1post and T1pre with AUC of 0.783 and 0.745,respectively. The combinations of two parameters (T1pre+T1post) improved the diagnostic performance (AUC=0.850) compared to the single parameter. A combined multi-parameter model (T1pre+T1post+ADC) was established with the highest diagnostic efficacy (AUC=0.901). Conclusions:The combinations of the two techniques to construct a multiparametric combined model of relaxation quantitative parameters (T1pre,T1post) combined with ADC values have a good diagnostic value in differentiating PD and TRC.关键词
胶质瘤/合成磁共振成像/磁共振成像/多重灵敏度编码/复发/治疗相关改变Key words
glioma/synthetic magnetic resonance imaging/magnetic resonance imaging/multiplexed sensitivity-encoding/progressive disease/treatment-related change分类
医药卫生引用本文复制引用
吕瑞瑞,杨治花,党佩,黄雪莹,马文富,金一萱,吕鸿洁,王晓东..合成MRI联合MUSE-DWI鉴别胶质瘤复发和治疗相关改变的应用研究[J].磁共振成像,2024,15(7):81-86,6.基金项目
宁夏回族自治区自然科学基金项目(No.2023AAC03557) （No.2023AAC03557）
宁医大总院2023年新入职硕士人才培养项目(编号:[2023]394号) Natural Science Foundation of Ningxia Hui Autonomous Region(No.2023AAC03557) （编号:[2023]394号）
2023 New Master Talent Training Program of General Hospital of Ningxia Medical University[No.(2023)394]. （2023）
