动物医学进展2024，Vol.45Issue(9)：49-56,8.
苍朴乌梅散对大鼠的急性毒性及亚慢性毒性研究
Study on Acute and Subchronic Toxicities of Cangpu Wumei Powder in Rats
摘要
Abstract
In order to evaluate the safety of Cangpu Wumei Powder,the acute and subchronic toxicity tests of Cangpu Wumei Powder were carried out respectively.In the acute toxicity test,the feeding and mental status of SD rats were observed for 7 days after administration of the drug by oral gavage.In the subchronic toxicity test,80 SD rats(half male and half female)were randomly divided into the blank control group and the low,medium and high dose groups of Cangpu Wumei Powder.After 30 days of continuous adminis-tration of Cangpu Wumei Powder,the haematology,blood biochemical indexes and histopathological analy-ses of organs were carried out in each group.The results showed that no rats died in the acute toxicity test.In the subchronic toxicity test,the high-dose group showed significant differences from the blank control group in body weights,haematological and biochemical assays;the same was true for the medium-dose group.while there were no statistically significant differences in body weights,haematological and biochemical indexes,or-gan indexes,and histopathology between the low-dose group at 10 g/kg and the control group(P＞0.05).The re-sults showed that the LD50 of Cangpu Wumei Powder in rats was＞5 000 mg/kg,and the safety of continuous ad-ministration of 10 g/kg(25 times of the clinically recommended dosage)for 30 d in SD rats was good.关键词
苍朴乌梅散/大鼠/急性毒性/亚慢性毒性Key words
Cangpu Wumei Powder/rat/acute toxicity/subchronic toxicity分类
农业科技引用本文复制引用
方人来,易首利,郭小庆,石祥民,周家芳,谢小东,胡庭俊..苍朴乌梅散对大鼠的急性毒性及亚慢性毒性研究[J].动物医学进展,2024,45(9):49-56,8.基金项目
广西研究生教育创新计划项目(JGY2023015) （JGY2023015）
广西大学大学生创新创业训练计划(20220100619,S202310593294) （20220100619,S202310593294）
广西大学巴马产教融合研究院人才科技专项(202100182,20220024) （202100182,20220024）
