苍朴乌梅散对大鼠的急性毒性及亚慢性毒性研究OA北大核心CSTPCD

In order to evaluate the safety of Cangpu Wumei Powder,the acute and subchronic toxicity tests of Cangpu Wumei Powder were carried out respectively.In the acute toxicity test,the feeding and mental status of SD rats were observed for 7 days after administration of the drug by oral gavage.In the subchronic toxicity test,80 SD rats(half male and half female)were randomly divided into the blank control group and the low,medium and high dose groups of Cangpu Wumei Powder.After 30 days of continuous adminis-tration of Cangpu Wumei Powder,the haematology,blood biochemical indexes and histopathological analy-ses of organs were carried out in each group.The results showed that no rats died in the acute toxicity test.In the subchronic toxicity test,the high-dose group showed significant differences from the blank control group in body weights,haematological and biochemical assays;the same was true for the medium-dose group.while there were no statistically significant differences in body weights,haematological and biochemical indexes,or-gan indexes,and histopathology between the low-dose group at 10 g/kg and the control group(P＞0.05).The re-sults showed that the LD50 of Cangpu Wumei Powder in rats was＞5 000 mg/kg,and the safety of continuous ad-ministration of 10 g/kg(25 times of the clinically recommended dosage)for 30 d in SD rats was good.