腹腔镜外科杂志2024，Vol.29Issue(7)：492-496,5.DOI:10.13499/j.cnki.fqjwkzz.2024.07.492
吲哚美辛栓联合胰管支架置入对术后胰腺炎高危人群的影响
Effect of indomethacin suppositories combined with pancreatic duct stenting on population at high risk of postoperative pancreatitis
摘要
Abstract
Objective:To investigate the effects of indomethacin suppositories combined with pancreatic duct stent implantation on inflammatory factors and immune function in patients with high risk of post endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP).Methods:In this prospective study,234 patients at high risk of PEP who received ERCP between Jul.2022 and Jun.2023 were selected as subjects.The patients were divided into stent group(pancreatic duct stent implantation,n=80),indometha-cin suppository group(rectal administration of indomethacin suppository,n=78),and combined group(indomethacin suppository com-bined with pancreatic duct stent implantation,n=76)by envelope method.The relevant inflammatory factors,immune function before or after operation,PEP occurrence,incidence of severe PEP,symptom remission time and hospital stay of the three groups were compared.Results:Before the surgery,there was no significant difference in the levels of inflammatory factors and immune function among the three groups(P＞0.05).The levels of inflammatory factor interleukin-6,interleukin-10 and C-reactive protein in the combined group were lower than those in the stent group and indomethacin suppository group,the CD4+and CD4+/CD8+levels in the combined group were higher than the other two groups,and the CD8+level in the combined group was lower than the other two groups,and the differences were statistically significant(P＜0.05).There was no significant difference in the occurrence of PEP and the incidence of severe PEP among the three groups(P＞0.05).The duration of pain relief and hospitalization in the combined group were shorter than those in the other two groups(P＜0.05).Conclusions:Indomethacin suppository and pancreatic duct stenting can reduce the inflammation of PEP high-risk population,and improve the immune function of patients.Moreover,it can shorten the postoperative pain relief time and hospi-tal stay.关键词
术后胰腺炎/胰胆管造影术,内窥镜逆行/胰管支架/吲哚美辛栓Key words
Postoperative pancreatitis/Cholangiopancreatography,endoscopic retrograde/Pancreatic duct stent/Indomethacin suppository分类
医药卫生引用本文复制引用
金鹏飞,董源,武振东..吲哚美辛栓联合胰管支架置入对术后胰腺炎高危人群的影响[J].腹腔镜外科杂志,2024,29(7):492-496,5.基金项目
河北省廊坊市科学技术研究与发展计划(2023013042) （2023013042）
