分析化学2024，Vol.52Issue(8)：1172-1181,10.DOI:10.19756/j.issn.0253-3820.241152
提高离子迁移谱性能的双效应Tyndall-Powell门控方法研究
Enhancing Performance of Ion Mobility Spectrometry Based on a Dual Effect Tyndall-Powell Gate Controlling Method
摘要
Abstract
Ion mobility spectroscopy(IMS)has many advantages such as fast detection speed,high sensitivity,and portability,and thus plays an important role in on-site detection of chemical agents,explosives,drugs,environmental pollutants,and other pollutants.As a key component of IMS,the ion number density and temporal width of the injected ion packets directly determine the IMS detection sensitivity and resolution.In yhis study,the dual-parallel-grid structure of Tyndall-Powell gate(TPG),which could effectively isolate the electric fields within the ionization region,gate region,and drift region,was utilized to develop a dual effect TPG gating method for simultaneously enhancing the mobility discrimination reduction and ion packet temporal width compression,thereby improving the IMS performance.A TPG-IMS platform was thus built up and the effects of parameters such as gate opening pulsed width,gate penetration voltage,and ion injection voltage on the sensitivity and resolving power of IMS were systematically investigated using the dual-effect TPG gating method.The results demonstrated that,when detecting diethyl phosphate(DEP)and diethyl methylphosphate(DEMP)mixture using the dual effect TPG gating method,the peak currents of(DEP)2H+and(DEP·DEMP)H+ions with low K0 values were increased by 18 and 45 times respectively,while maintaining a high resolution of about 90.The limits of detection for DEP and DEMP were decreased from 4 ppb(10-9)to 235 ppt(10-12)and from 5 ppb to 156 ppt,respectively.This gating method only regulated the potential of the TPG grid adjacent to the drift region,without changing the structure of the ion mobility tube,making it convenient to apply on existing commercial instruments.关键词
离子迁移谱/双平行栅离子门/迁移率歧视/离子团时域压缩/综合门控效能Key words
Ion mobility spectrometry/Parallel dual-grid ion gate/Mobility discrimination/Temporal compression/Comprehensive gating performance引用本文复制引用
张根伟,杨其穆,徐一仟,杨杰,潘慢慢,蒋丹丹,陈创..提高离子迁移谱性能的双效应Tyndall-Powell门控方法研究[J].分析化学,2024,52(8):1172-1181,10.基金项目
国家自然科学基金项目(Nos.21974141,22027804)、辽宁省自然科学基金项目(Nos.2022-MS-016,2022-MS-019)、国民核生化灾害防护国家重点实验室科研基金项目(No.SKLNBC2021-16)和大连化物所创新研究基金项目(Nos.DICPI202141,DICPI202422)资助. Supported by the National Natural Science Foundation of China(Nos.21974141,22027804),the Liaoning Natural Science Foundation(Nos.2022-MS-016,2022-MS-019),the State Key Laboratory of NBC Protection for Civilian(No.SKLNBC2021-16)and the Dalian Institute of Chemical Physics,Chinese Academy of Sciences(Nos.DICPI202141,DICPI202422). （Nos.21974141,22027804）
