广东医学2024，Vol.45Issue(8)：981-987,7.DOI:10.13820/j.cnki.gdyx.20234061
耐碳青霉烯类肺炎克雷伯菌血流感染危险因素及预后分析
Risk factors and prognosis of carbapenem-resistant Klebsiella pneumoniae bloodstream infection
摘要
Abstract
Objective To explore the risk factors and clinical prognosis of patients with carbapenem-resistant Klebsiella pneumoniae(CRKP)bloodstream infection in hospital,and provide a scientific basis for the effective control of CRKP bloodstream infection.Methods Adopting a case-control study in a 1:2 ratio,cases of CRKP bloodstream infec-tion in Guangdong Provincial People's Hospital from January 2012 to December 2022 were collected and analyzed through retrospective analysis.Based on the results of the blood culture for 28 days,the CRKP group was divided into a survival group and a death group.Meanwhile,univariate and multivariate logistics regression were applied to analyze the related risk factors of CRKP bloodstream infection and the important risk factors affecting the prognosis of CRKP bloodstream infec-tion in 28 days.Kalan-Meier was employed to plot the survival curve.Results Central venous intubation(P=0.042),other site infections(P=0.028),and previous use of antibiotics(P＜0.001)may be important risk factors for CRKP bloodstream infection in the hospital.Cardiovascular and cerebrovascular diseases(P=0.029)were the main risk factors for patients infected with CRKP dead in 28 days,and the death rate of patients in the CRKP group was significantly higher than that in the carbapenem-sensitive Klebsiella pneumoniae(CSKP)group(P＜0.001).Conclusion The high fatali-ty rate of CRKP bloodstream infection seriously affects the prognosis of patients.Hence,the clinic should endeavor to pro-tect patients from infection,reduce the occurrence of CRKP bloodstream infection,and curb the spread of CRKP in hospital.关键词
耐碳青霉烯肺炎克雷伯菌/血流感染/危险因素/临床预后Key words
carbapenem-resistant Klebsiella pneumoniae/bloodstream infection/risk factors/clinical prognosis分类
基础医学引用本文复制引用
禄梦笛,蔡依含,凌勇,张莉滟,赵越..耐碳青霉烯类肺炎克雷伯菌血流感染危险因素及预后分析[J].广东医学,2024,45(8):981-987,7.基金项目
广东省基础与应用基础研究基金项目(2021A1515220022) （2021A1515220022）
