国际妇产科学杂志2024，Vol.51Issue(4)：361-365,5.DOI:10.12280/gjfckx.20240393
多倍体肿瘤巨细胞对肿瘤耐药作用机制的研究进展
Research Progress on the Mechanism of Tumor Resistance in Polyploid Giant Cancer Cells
摘要
Abstract
Chemotherapy is a commonly used method for tumor treatment,which has a positive effect in the early stage of tumor treatment.However,as the chemotherapy course increases,the sensitivity of tumor cells to chemotherapy drugs gradually weakens,leading to chemotherapy resistance.Tumor drug resistance is a complex process mediated by multiple factors,which is currently believed to be related to tumor cell stemness,heterogeneity,tumor immune microenvironment,and increased chemotherapy drug transport and efflux.But the specific mechanism is not yet clear.Polyploid giant cancer cells(PGCCs)are a special subset of tumor cells with increased volume and abundant nuclei.Research has found that PGCC generally exist in colorectal cancer,breast cancer,ovarian cancer and other tumors,and were closely related to the occurrence,metastasis,drug resistance and recurrence of tumors.This paper describes the formation and significance of the research progress of PGCC in tumors,and expounds the possible mechanism of PGCC causing drug resistance from the perspective of its special mechanism,autophagy,aging and DNA repair,so as to provide a possible strategy for improving tumor drug resistance.关键词
肿瘤/多倍体肿瘤巨细胞/抗药性,肿瘤/自噬/DNA修复Key words
Neoplasms/Polyploid giant cancer cells/Drug resistance,neoplasm/Autophagy/DNA repair引用本文复制引用
丁义玲,鲁娣,宋殿荣..多倍体肿瘤巨细胞对肿瘤耐药作用机制的研究进展[J].国际妇产科学杂志,2024,51(4):361-365,5.基金项目
天津市教育委员会科研计划项目(2021KJ162) （2021KJ162）
