国际妇产科学杂志2024，Vol.51Issue(4)：366-369,4.DOI:10.12280/gjfckx.20240167
甲基化检测用于卵巢癌筛查和诊断的研究进展
Advances in Methylation Detection for Ovarian Cancer Screening and Diagnosis
摘要
Abstract
Ovarian cancer has the highest mortality rate and poorest prognosis in gynecologic cancers.Presently,there is a lack of effective tools for early diagnosis and early screening for ovarian cancer.Methylation plays a key role in the origin and progression of ovarian cancer.Based on liquid biopsy technique,several studies had been conducted to analyze the efficacy of cell-free DNA methylation detection in diagnosing ovarian cancer.The overall median accuracy of cell-free DNA methylation reached 85％,which is superior to traditional protein molecular markers such as CA125.The findings from methylation detection in ovarian cancer tissue were also closely related to patients'survival outcomes and drug sensitivity.The advances and improvement of methylation assays for ovarian cancer hold promise for providing novel direction and opportunities in exploring molecular strategies for diagnosing and treating.关键词
卵巢肿瘤/甲基化/表观基因组学/早期诊断/生物标记,肿瘤Key words
Ovarian neoplasms/Methylation/Epigenomics/Early diagnosis/Biomarkers,tumor引用本文复制引用
苏海绮,李雷..甲基化检测用于卵巢癌筛查和诊断的研究进展[J].国际妇产科学杂志,2024,51(4):366-369,4.基金项目
中国医学科学院临床与转化医学研究专项项目(2022-12M-C&T-B-033) （2022-12M-C&T-B-033）
