国际妇产科学杂志2024，Vol.51Issue(4)：370-374,5.DOI:10.12280/gjfckx.20240329
外泌体在卵巢癌血管生成中的研究进展
Research Advances of Exosomes in Angiogenesis of Ovarian Cancer
摘要
Abstract
In the treatment of ovarian cancer,tumor cells often become resistant to chemotherapy drugs,leading to weakened or ineffective treatment outcomes.Therefore,anti-angiogenesis therapy serves as an important adjunctive treatment,can effectively slow disease progression by synergizing with other treatment modalities through various mechanisms.Exosomes,extracellular vesicles secreted by living cells,carry a variety of genetic materials and play crucial roles in cell communication within the tumor microenvironment.Studies have shown that exosomes derived from tumor cells and other cell sources can influence angiogenesis and other tumor-related processes by releasing non-coding RNAs,proteins,and other genetic materials.Utilizing exosomes to target specific proteins or as exogenous carriers for encapsulate therapeutic agents has become an important strategy for anti-angiogenesis therapy in ovarian cancer.This review summarized the regulatory mechanism of exosomes on angiogenesis in ovarian cancer and it also explores the potential of exosomes as anti-angiogenic agents,providing a theoretical basis for new treatment methods.关键词
外泌体/卵巢肿瘤/新生血管化/治疗/肿瘤微环境Key words
Exosomes/Ovarian neoplasms/Neovascularization/Therapy/Tumor microenvironment引用本文复制引用
张静怡,刘东哲,陈秀慧..外泌体在卵巢癌血管生成中的研究进展[J].国际妇产科学杂志,2024,51(4):370-374,5.基金项目
国家自然科学基金(81802592) （81802592）
中国博士后科学基金会基金(2018M641854) （2018M641854）
