国际妇产科学杂志2024，Vol.51Issue(4)：375-379,5.DOI:10.12280/gjfckx.20240245
线粒体在子宫内膜癌中的作用及治疗
The Role and Treatment of Mitochondria in Endometrial Carcinoma
张益田 1李小丽2
作者信息
- 1. 030000 太原,山西医科大学
- 2. 山西省儿童医院,山西省妇幼保健院
- 折叠
摘要
Abstract
Mitochondria are dynamic,semi-autonomous organelles widely found in mammalian cells and play an important role in maintaining normal endometrial cell homeostasis.Endometrial carcinoma is a common malignant tumor in women,and its age of onset is showing a trend towards younger age,so improving the ability to treat endometrial carcinoma is important to improve its prognosis.Recent studies have shown that abnormal mitochondrial biosynthesis process,dysregulation of mitochondrial dynamics,and mitochondrial dysfunction are closely related to the occurrence and development of endometrial carcinoma.Mitochondria also show great potential in endometrial carcinoma treatment,such as induction of apoptosis and targeting of mitochondria-associated endometrial carcinoma stem cells.Deeply understanding of the role of mitochondria in the pathogenesis of endometrial carcinoma will provide new perspectives for endometrial carcinoma treatment.关键词
线粒体/子宫内膜肿瘤/DNA,线粒体/线粒体动力学/调节细胞死亡/线粒体生物合成Key words
Mitochondria/Endometrial neoplasms/DNA,mitochondrial/Mitochondrial dynamics/Regulated cell death/Mitochondrial biosynthesis引用本文复制引用
张益田,李小丽..线粒体在子宫内膜癌中的作用及治疗[J].国际妇产科学杂志,2024,51(4):375-379,5.
