国际妇产科学杂志2024，Vol.51Issue(4)：438-441,4.DOI:10.12280/gjfckx.20240121
免疫检查点抑制剂相关严重贫血一例
Severe Anemia Associated with Immune Checkpoint Inhibitor:A Case Report
杨祖娇 1宁显灵 1刘洲梅 1王文艳 1尹桥仙 1杨谢兰1
作者信息
- 1. 650118 云南省肿瘤医院/昆明医科大学第三附属医院妇科
- 折叠
摘要
Abstract
We report a case of severe anemia in a patient with recurrence of ovarian cancer who underwent comprehensive treatment with the immune checkpoint inhibitor(ICI)Tislelizumab combined with the paclitaxel+carboplatin(TC)regimen.The patient's medical history and additional diagnostic tests led to the consideration of autoimmune hemolytic anemia.Following a blood transfusion,administration of high-dose corticosteroids and immunoglobulin,and consistent oral cyclosporine soft capsule maintenance therapy for over 2 months,the individual's hemoglobin concentration gradually increased to 110 g/L.Subsequent monitoring over a 3-month period indicated sustained stability in the hemoglobin levels.In patients receiving ICI therapy combined with cytotoxic chemotherapy or radiotherapy,severe hematological adverse reactions attributed to ICI are very rare among immune-related events.Early diagnosis is challenging,as these reactions can easily be confused with bone marrow suppression caused by radiotherapy and chemotherapy.The earlier use of corticosteroids,the better the treatment outcome and prognosis of adverse reactions caused by ICI.Therefore,when combining clinical anti-tumor therapy with ICI in patients,it is important to pay attention to adverse reactions in the hematologic system and promptly identify them.关键词
替雷利珠单抗/贫血,溶血性,自身免疫性/免疫检查点抑制剂/免疫相关不良反应/病例报告Key words
Tislelizumab/Anemia,hemolytic,autoimmune/Immune checkpoint inhibitors/Immune-related adverse events/Case reports引用本文复制引用
杨祖娇,宁显灵,刘洲梅,王文艳,尹桥仙,杨谢兰..免疫检查点抑制剂相关严重贫血一例[J].国际妇产科学杂志,2024,51(4):438-441,4.
