槲皮素通过NF-κB信号通路调控银屑病角质形成细胞的增殖、炎症和氧化应激OACSTPCD
Quercetin regulates proliferation,inflammation,and oxidative stress in psoriatic keratinocytes via the NF-κB signaling pathway
目的:槲皮素在银屑病治疗中具有良好的潜力,然而有关其具体的作用机制仍不清楚.本研究探讨槲皮素是否可通过核转录因子-κB(nuclear transcription factor-κB,NF-κB)信号通路调控银屑病角质形成细胞的增殖、炎症和氧化应激.方法:培养人表皮角质形成细胞(human epidermal keratinocytes,HaCaT),通过肿瘤坏死因子α(tumor necrosis factor α,TNF-α)诱导,建立银屑病…查看全部>>
Objective:Quercetin holds promising potential in the treatment of psoriasis,yet its specific mechanisms of action remain unclear.This study investigates whether quercetin can regulate the proliferation,inflammation,and oxidative stress of psoriatic keratinocytes via the nuclear transcription factor kappa B(NF-κB)signaling pathway. Methods:Human epidermal keratinocytes(HaCaT)were cultured and induced with tumor necrosis factor α(TNF-α)to establish a psoriasis…查看全部>>
朱宇;徐文静;张元瑜;段晓诚
湖南中医药大学第一附属医院皮肤科,长沙 410007湖南中医药大学第一附属医院皮肤科,长沙 410007湖南中医药大学第一附属医院皮肤科,长沙 410007湖南中医药大学第一附属医院皮肤科,长沙 410007
银屑病槲皮素增殖炎症氧化应激
psoriasisquercetinproliferationinflammationoxidative stress
《临床与病理杂志》 2024 (5)
647-655,9
湖南省自然科学基金(2023JJ60490)湖南省中医药科研计划项目(E2022004)长沙市自然科学基金(KQ2202457)湖南中医药大学校级科研基金(2022YYZK005)湖南中医药大学校级研究生创新课题基金(2022CX149).This work was supported by the Natural Science Foundation of Hunan Province(2023JJ60490),the Scientific Research Project of Traditional Chinese Medicine in Hunan Province(E2022004),the Changsha Natural Science Foundation(KQ2202457),the University Level Scientific Research Fund of Hunan University of Chinese Medicine(2022YYZK005),and the University Level Graduate Innovation Fund of Hunan University of Chinese Medicine(2022CX149),China.
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