临床与病理杂志2024，Vol.44Issue(5)：681-688,8.DOI:10.11817/j.issn.2095-6959.2024.240002
血清FGF21和SIRT3水平对慢性心力衰竭患者病情及预后评估的价值
Value of serum FGF21 and SIRT3 levels in assessing the condition and prognosis of patients with chronic heart failure
摘要
Abstract
Objective:Early assessment of the condition and prognosis of patients with chronic heart failure(CHF)helps reduce mortality and improve prognosis.This study aims to explore the levels of serum fibroblast growth factor 21(FGF21)and silent information regulator factor 2 related enzyme 3(SIRT3)in CHF patients and their value in assessing the patients'condition and prognosis. Methods:A total of 164 patients diagnosed with CHF from January 2021 to June 2022 were selected as the disease group,and 160 healthy individuals were selected as the control group.Serum FGF21 and SIRT3 levels were detected using enzyme-linked immunosorbent assay(ELISA).The left ventricular weight index(LVMI),left ventricular end-diastolic internal diameter(LVEDD),left atrium internal diameter(LAD),and left ventricular ejection fraction(LVEF)were measured using a Doppler ultrasound device.Pearson correlation analysis was used to assess the correlations between serum FGF21,SIRT3,and LVMI,LVEDD,and LAD.The diagnostic value of serum FGF21,and SIRT3 for CHF prognosis was analyzed using receiver operator characteristic(ROC)curves.The relationship between FGF21 and SIRT3 and CHF prognosis was analyzed by the Kaplan-Meier method. Results:Compared to the control group,the disease group had higher levels of LVMI,LVEDD,LAD,and FGF21,and lower levels of SIRT3(all P<0.05).There were statistically significant differences in serum FGF21 and SIRT3 levels among patients with different cardiac function grades(P<0.05).FGF21 levels were positively correlated with LVMI,LVEDD,and LAD,while SIRT3 levels were negatively correlated with LVMI,LVEDD,LAD,and FGF21 levels(all P<0.05).The area under the curve(AUC)for the combined diagnosis of CHF prognosis using FGF21 and SIRT3 was significantly greater than the AUC for FGF21 alone(Z=2.645,P=0.008)and SIRT3 alone(Z=2.738,P=0.006).The survival rate in the high FGF21 expression group was lower than in the low expression group(χ2=8.257,P=0.004),and the survival rate in the high SIRT3 expression group was higher than in the low expression group(χ2=15.305,P<0.001). Conclusion:Serum FGF21 levels are elevated and SIRT3 levels are decreased in CHF patients.The combination of FGF21 and SIRT3 has high application value in assessing the condition and prognosis of CHF patients.关键词
慢性心力衰竭/成纤维细胞生长因子21/沉默信息调节因子2相关酶3/预后/应用价值Key words
chronic heart failure/fibroblast growth factor 21/silent information regulator 2 related enzyme 3/prognosis/application value引用本文复制引用
饶培玲,郑裴裴..血清FGF21和SIRT3水平对慢性心力衰竭患者病情及预后评估的价值[J].临床与病理杂志,2024,44(5):681-688,8.基金项目
河南省卫生健康委员会资助项目(LHGJ20220934).This work was supported by the Henan Provincial Health Commission Project,China(LHGJ20220934). （LHGJ20220934）
