铁死亡与结直肠癌治疗OACSTPCD

Ferroptosis,a novel form of programmed cell death,is implicated in the occurrence and development of various diseases,including colorectal cancer(CRC).Morphologically and molecularly,ferroptosis is distinct from other forms of cell death such as pyroptosis,apoptosis,necrosis,and autophagy.As the understanding of tumor cell death deepens,inducing ferroptosis in tumor cells has emerged as a new therapeutic approach against CRC.Currently,ferroptosis-related genes are used as biomarkers for early screening and prognosis evaluation in CRC.Some drugs kill CRC cells by generating large amounts of reactive oxygen species,triggering ferroptosis.Targeted knockdown of ferroptosis gene solute carrier family 7 member 11(SLC7A11)can also induce ferroptosis,thereby disrupting CRC cells.Additionally,combining immunotherapy with ferroptosis by reducing the expression of glutathione peroxidase 4(GPX4)can potentially reverse resistance to the chemotherapy drug oxaliplatin and enhance its cytotoxic effects on CRC cells.Therefore,ferroptosis plays a crucial role in CRC treatment,and its future research prospects are promising.