临床与病理杂志2024，Vol.44Issue(5)：713-723,11.DOI:10.11817/j.issn.2095-6959.2024.230534
铁死亡与结直肠癌治疗
Ferroptosis and colorectal cancer treatment
张文 1张妍 2郭龙 2陈帅 2吴家乐 1李晓丹 3方学红 4叶华 2刘义2
作者信息
- 1. 广东医科大学药学院,广东东莞 523808
- 2. 广东医科大学药学院/广东省天然药物研究开发重点实验室,广东 湛江 524023
- 3. 深圳市龙华区人民医院药剂科,广东深圳 518109
- 4. 深圳市龙岗区妇幼保健院药剂科,广东 深圳 518172
- 折叠
摘要
Abstract
Ferroptosis,a novel form of programmed cell death,is implicated in the occurrence and development of various diseases,including colorectal cancer(CRC).Morphologically and molecularly,ferroptosis is distinct from other forms of cell death such as pyroptosis,apoptosis,necrosis,and autophagy.As the understanding of tumor cell death deepens,inducing ferroptosis in tumor cells has emerged as a new therapeutic approach against CRC.Currently,ferroptosis-related genes are used as biomarkers for early screening and prognosis evaluation in CRC.Some drugs kill CRC cells by generating large amounts of reactive oxygen species,triggering ferroptosis.Targeted knockdown of ferroptosis gene solute carrier family 7 member 11(SLC7A11)can also induce ferroptosis,thereby disrupting CRC cells.Additionally,combining immunotherapy with ferroptosis by reducing the expression of glutathione peroxidase 4(GPX4)can potentially reverse resistance to the chemotherapy drug oxaliplatin and enhance its cytotoxic effects on CRC cells.Therefore,ferroptosis plays a crucial role in CRC treatment,and its future research prospects are promising.关键词
铁死亡/结直肠癌/机制/治疗靶点Key words
ferroptosis/colorectal cancer/mechanism/therapeutic target引用本文复制引用
张文,张妍,郭龙,陈帅,吴家乐,李晓丹,方学红,叶华,刘义..铁死亡与结直肠癌治疗[J].临床与病理杂志,2024,44(5):713-723,11.
