临床与病理杂志2024，Vol.44Issue(5)：738-745,8.DOI:10.11817/j.issn.2095-6959.2024.230644
金属蛋白酶-7在特发性肺纤维化中的作用机制及应用进展
Mechanisms and application progress of metalloproteinase-7 in idiopathic pulmonary fibrosis
摘要
Abstract
Idiopathic pulmonary fibrosis is a chronic fibrotic interstitial lung disease with a poor prognosis and unknown etiology.Early diagnosis,accurate disease assessment,and timely clinical intervention can improve patient's outcomes.Matrix metalloproteinase-7 is an active mediator secreted by alveolar epithelial cells after lung injury.It is notable for its role in predicting the prognosis of idiopathic pulmonary fibrosis and has research value in targeted therapy.The structural and nucleotide composition polymorphisms that distinguish matrix metalloproteinase-7 from other matrix metalloproteinase members,lead its broad functional range and efficient up-regulation.By understanding the clinical applications and action pathways of matrix metalloproteinase-7,the study exploring whether inhibiting its concentration could benefit idiopathic pulmonary fibrosis patients could provide new insights for early disease control.关键词
特发性肺纤维化/基质金属蛋白酶-7/金属蛋白酶组织抑制剂/作用机制/生物标志物Key words
idiopathic pulmonary fibrosis/matrix metalloproteinase-7/tissue inhibitors of metalloproteinases/mechanism of action/biomarkers引用本文复制引用
郭春旭,张子璇,杜丽娟,闫莉..金属蛋白酶-7在特发性肺纤维化中的作用机制及应用进展[J].临床与病理杂志,2024,44(5):738-745,8.基金项目
河北省医学科学研究课题计划(20230300).This work was supported by the Medical Science Research Project of Hebei Province. （20230300）
