临床与病理杂志2024，Vol.44Issue(5)：781-786,6.DOI:10.11817/j.issn.2095-6959.2024.230312
肌纤维母细胞瘤伴黏液样变性1例并文献复习
Myofibroblastoma with myxoid degeneration:A case report and literature review
彭姣 1赵江映 1严春禄 1庞小君1
作者信息
- 1. 绵阳市中医医院病理科,四川绵阳 621000
- 折叠
摘要
Abstract
Myofibroblastoma(MFB)with myxoid degeneration is a rare benign mesenchymal tumor.A case of a 42-year-old female has been found a painless mass in the right inguinal region for 1 year.The mass was smooth on the surface,nodular,and gray-brown on the cross-section.Histologically,the tumor had a myxoid-rich background,with round or short spindle-shaped cells arranged in irregular bundles,eosinophilic cytoplasm,and some nuclei with prominent vacuoles.Immunohistochemistry showed that the tumor cells were diffusely positive for cluster of differentiation 34(CD34)and desmin,partially positive for smooth muscle actin(SMA),cluster of differentiation 56(CD56),and erythroblast transformation-specific related gene(ERG),with a proliferation index Ki-67 of about 5%.Fluorescence in situ hybridization(FISH)revealed a positive deletion of the retinoblastoma protein 1(RB1)gene and negative for nuclear receptor subfamily 4 group a member 3(NR4A3)and Ewing sarcoma breakpoint region 1(EWSR1)genes.Post-surgical follow-up for 3 to 24 months showed no local recurrence or distant metastasis.Diagnosis and differential diagnosis of MFB with myxoid degeneration depend on clinicopathological features,immunohistochemistry,and genetic testing.Simple surgical resection is the primary treatment,offering a good prognosis with no significant risk of recurrence.关键词
肌纤维母细胞瘤/黏液变性/结蛋白/CD34/视网膜母细胞瘤蛋白1Key words
myofibroblastoma/myxoid degeneration/desmin/CD34/retinoblastoma protein 1引用本文复制引用
彭姣,赵江映,严春禄,庞小君..肌纤维母细胞瘤伴黏液样变性1例并文献复习[J].临床与病理杂志,2024,44(5):781-786,6.
