工业微生物2024，Vol.54Issue(4)：22-24,3.DOI:10.3969/j.issn.1001-6678.2024.04.008
基因工程益生菌在炎症性肠病中的研究进展
Research Progress of Genetically Engineered Probiotics in Inflammatory Bowel Disease
摘要
Abstract
Inflammatory Bowel Disease(IBD)is a chronic and recurrent inflammatory disease of the bowel.The current treatment methods have some problems such as low clinical remission rate,high recurrence rate and obvious side effects,so the development of novel and efficient treatment strategies has become a global goal in this field.As one of the emerging therapies in the field of IBD,engineered probiotic therapy brings new possibilities for breaking through the bottleneck of IBD treatment.This article describes the basic problems involved in the design and construction of genetically engineered probiotics,and summarizes the application of engineered probiotics in the diagnosis and clinical treatment of IBD,in order to provide new perspectives and ideas for the clinical diagnosis and treatment of IBD.关键词
益生菌/炎症性肠病/合成生物学/基因工程Key words
probiotics/inflammatory bowel disease/synthetic biology/genetic engineering引用本文复制引用
赵菊阳,陈曦,李丽梅,王新一,吕梦圆..基因工程益生菌在炎症性肠病中的研究进展[J].工业微生物,2024,54(4):22-24,3.基金项目
2022年度大连大学学科建设专项-学科交叉项目"重点类""基于RPA/CRISPR/Cas9突变富集技术构建循环肿瘤DNA纳米生物传感新方法及其应用研究"(编号:DLUXK-2022-ZD-002). （编号:DLUXK-2022-ZD-002）
