湖北民族大学学报（自然科学版）2024，Vol.42Issue(3)：330-336,7.DOI:10.13501/j.cnki.42-1908/n.2024.09.004
基于网络药理学与分子对接探讨淫羊藿治疗类风湿性关节炎的作用机制
Exploring the Mechanism of Epimedium brevicornu Maxim.for Treating Rheumatoid Arthritis Based on Network Pharmacology and Molecular Docking
摘要
Abstract
To gain a deeper understanding of the mechanism by which Epimedium brevicornu Maxim.treats rheumatoid arthritis(RA),network pharmacology and molecular docking techniques for analysis were employed.The intersection target proteins of E.brevicornu Maxim.and RA through databases and related software were obtained,the protein-protein interaction(PPI)network and ″medicinal material-component-target″ interaction network were constructed,the target proteins were enriched and analyzed,and protein molecule docking was performed.The results indicated that the core target proteins of E.brevicornu Maxim.for treating RA might be TNF,AKT1,TP53,ALB,SRC,etc.The active ingredients might be β-sitosterol,8-isopentenyl kaempferol,sitosterol,kaempferol,luteolin,quercetin,etc.The signal pathway might be the signal pathway in cancer,lipid,and atherosclerosis.The molecular docking showed that the active ingredients of E.brevicornu Maxim.for treating RA had excellent binding activity with target proteins.The results demonstrated that E.brevicornu Maxim.,in the treatment of RA,possessed characteristics of multiple components,multiple targets,and multiple pathways,providing a solid theoretical foundation for its experimental research and clinical treatment.关键词
淫羊藿/类风湿性关节炎/网络药理学/分子对接/作用机制/有效活性成分/β-谷甾醇Key words
Epimedium brevicornu Maxim./rheumatoid arthritis/network pharmacology/molecular docking/action mechanism/active ingredients/β-sitosterol分类
农业科技引用本文复制引用
兰德淼,姚锦坤,嵇常青,肖强..基于网络药理学与分子对接探讨淫羊藿治疗类风湿性关节炎的作用机制[J].湖北民族大学学报（自然科学版）,2024,42(3):330-336,7.基金项目
国家自然科学基金项目(31260057) （31260057）
湖北省科技厅技术创新重大专项资助项目(2019ACA120) （2019ACA120）
湖北省自然科学基金项目(2023AFD077). （2023AFD077）
