河北医学2024，Vol.30Issue(8)：1316-1319,4.DOI:10.3969/j.issn.1006-6233.2024.08.015
帕金森病患者血清CysC SAA水平的变化及其与认知功能损伤的关联性分析
Changes in Serum Cysc SAA Levels and Their Correlation with Cognitive Impairment in Parkinson's Disease Patients
摘要
Abstract
Objective:To analyze the changes in levels of serum cystatin C(CysC)and SAA in patients with Parkinson's disease(PD)and their relationship with cognitive impairment.Methods:Patients who re-ceived treatment and physical examination in the hospital from August 2019 to August 2023 were selected as the research subjects,including 150 PD patients as the case group and 90 healthy volunteers as the control group.Cognitive function was assessed using Montreal Cognitive Assessment Scale(MoCA).The general da-ta,serum CysC and SAA levels,and MoCA scores were compared.The levels of CysC and SAA were com-pared among patients with different Hoehn and Yahr(H-Y)stages.The CysC and SAA levels were compared between the case group and the control group.The correlation of CysC and SAA with H-Y staging and MoCA score was analyzed using Pearson analysis.Results:The levels of CysC and SAA in the case group were high-er while the MoCA score was lower than in the control group(P＜0.05).CysC and SAA revealed the control group＜the early PD group＜the middle and late PD group,while MoCA score revealed the control group＞the early PD group＞the middle and late PD group(P＜0.05).CysC and SAA levels revealed the control group＜normal cognition group＜cognitive impairment group(P＜0.05).The levels of serum CysC and SAA in PD patients were positively correlated with H-Y staging(r=0.610,0.565,P＜0.05),and were negative-ly associated with MoCA score(r=-0.352,-0.533,P＜0.05).Conclusion:The levels of CysC and SAA in the serum of PD patients are increased.With the increase of H-Y stage,the levels of CysC and SAA rose while the MoCA score decreased.The levels of serum CysC and SAA in PD patients were positively correlated with H-Y staging and negatively correlated with MoCA score.关键词
帕金森/胱抑素C/淀粉样蛋白A/认知功能损伤/相关性Key words
Parkinson's disease/Cystatin C/Serum amyloid A/Cognitive impairment/Cor-relation引用本文复制引用
林宝平,朱作权,桂心,肖强,齐闯,汪世高..帕金森病患者血清CysC SAA水平的变化及其与认知功能损伤的关联性分析[J].河北医学,2024,30(8):1316-1319,4.基金项目
湖北省科技计划项目,(编号:2018CFC804) （编号:2018CFC804）
