河北医学2024，Vol.30Issue(8)：1349-1353,5.DOI:10.3969/j.issn.1006-6233.2024.08.022
bFGF联合超声骨刀在下颌阻生牙拔除中的应用研究
Application Study of bFGF Combined with Ultrasonic Bone Scalpel in Removal of Impacted Mandibular Teeth
摘要
Abstract
Objective:To explore the application effectiveness of recombinant bovine basic fibroblast growth factor(bFGF)combined with ultrasonic bone scalpel in the removal of impacted mandibular teeth.Methods:A total of 105 patients with impacted mandibular teeth treated at our hospital from October 2020 to October 2023 were randomly divided into a control group(n=52)and an observation group(n=53)using simple random grouping.The control group underwent bFGF combined with conventional rotary drilling for ex-traction,while the observation group underwent bFGF combined with ultrasonic bone scalpel for extraction.Surgical-related indicators,clinical treatment outcomes,postoperative swelling,restricted mouth opening re-covery,expression levels of inflammatory factors[tumor necrosis factor-alpha(TNF-α),intercellular adhe-sion molecule 1(ICAM1),myeloperoxidase(MPO)]in gingival crevicular fluid,and dry socket occurrence were compared between the two groups.Results:The operation time and intraoperative blood loss in the obser-vation group were significantly lower than those in the control group(P＜0.05).Before and after surgery,the improvement in systolic blood pressure,diastolic blood pressure,and blood glucose levels in the observation group was lower than that in the control group(P＜0.05).The excellent and good treatment rate in the obser-vation group was 98.11%,which was higher than 82.69%in the control group(P＜0.05).Postoperative swelling and incidence of restricted mouth opening were lower in the observation group compared to the control group(P＜0.05).The increase in TNF-α,ICAM1,and MPO levels in the gingival crevicular fluid was lower in the observation group than in the control group(P＜0.05).The total incidence of complications in the ob-servation group was lower than that in the control group(P＜0.05).Conclusion:bFGF combined with ultra-sonic bone scalpel for the treatment of impacted mandibular teeth is effective,improves inflammatory responses in gingival crevicular fluid,and reduces the risk of complications.关键词
超声骨刀/重组牛碱性成纤维细胞生长因子/下颌阻生牙Key words
Ultrasonic bone scalpel/Recombinant bovine basic fibroblast growth factor/Impact-ed mandibular teeth引用本文复制引用
魏恩典,伏晓,游景秀..bFGF联合超声骨刀在下颌阻生牙拔除中的应用研究[J].河北医学,2024,30(8):1349-1353,5.基金项目
2022年安徽省重点研究与开发计划项目,(编号:2022e07020037) （编号:2022e07020037）
