中国实用神经疾病杂志2024，Vol.27Issue(9)：1093-1097,5.DOI:10.12083/SYSJ.241088
颅内动脉直径与脑小血管病患者认知功能的关系
Relationship between intracranial artery diameter and cognitive function in patients with cerebral small vessel disease
摘要
Abstract
Objective To discuss the possible relation between intracranial artery diameter and cognitive function in patients with cerebral small vessel disease(CSVD),in order to furnish new perspectives for the early recognition,diagnosis,intervention and prognosis of vascular cognitive impairment(VCI)patients.Methods A total of 151 CSVD patients hospitalized in the Second Affiliated Hospital of Zhengzhou University or Xinzheng Public People's Hospital from January 2022 to December 2023 were retrospectively included.Montreal cognitive assessment(MoCA)scale was used to assess the cognitive function and separate each participant into the normal cognitive function group(88 cases)and the cognitive dysfunction group(63 cases).3D-slicer software was used to process the original MRI images of the patients,and the brain artery remodeling(BAR)score was obtained.According to BAR score,the patients were divided into intracranial artery diameter narrowing group(58 cases),intracranial artery diameter average group(37 cases),and intracranial artery diameter expansion group(56 cases).Logistic regression was used to analyze the relationship between intracranial artery diameter and cognitive dysfunction,and Pearson correlation was used to analyze the relationship between intracranial artery diameter and the total score of MoCA and each subitem of MoCA score.Results The result of Logistic analysis showed that intracranial artery dilation(OR=1.214,95%CI:1.127-1.307,P<0.01)were risk factors for cognitive dysfunction.Pearson correlation analysis showed that the intracranial artery dilation has inverse correlation with MoCA overall scores(r=-0.306,P<0.001),visual space and executive function(r=-0.237,P=0.003),language(r=-0.238,P=0.003),abstraction(r=-0.160,P=0.049),delayed recall(r=-0.180,P=0.027),and orientation(r=-0.163,P=0.046).Conclusion Intracranial artery diameter dilation are risk factors for cognitive impairment patients with CSVD.The dilation of intracranial artery diameter has inverse correlation with the overall score of MoCA after adjusted,visual spatial and executive capability,language,abstraction,delayed reminiscence,and orientation.关键词
脑小血管病/颅内动脉直径/认知功能障碍/脑萎缩/线性测量/危险因素Key words
Cerebral small vessel disease/Intracranial artery diameter/Cognitive dysfunction/Encephalatrophy/Linear measurement/Risk factor分类
医药卫生引用本文复制引用
邢媛媛,路畅,白宏英,姚燕雯,陈静,李彩霞..颅内动脉直径与脑小血管病患者认知功能的关系[J].中国实用神经疾病杂志,2024,27(9):1093-1097,5.基金项目
河南省医学科技攻关计划联合共建项目(编号:LHGJ20230366) （编号:LHGJ20230366）
