颅内动脉直径与脑小血管病患者认知功能的关系OACSTPCD
Relationship between intracranial artery diameter and cognitive function in patients with cerebral small vessel disease
目的 探讨颅内动脉直径与脑小血管病(CSVD)患者认知功能之间可能存在的关系,以求为血管性认知功能障碍(VCI)患者的早期识别、诊断及预后提供新的思路.方法 回顾性分析2022-01-2023-12在郑州大学第二附属医院及新郑市公立人民医院住院的151例CSVD患者,采用蒙特利尔认知量表(MoCA)评估受试者的认知功能情况,分为认知功能正常组88例和认知功能障碍组63例,使用3D-Slicer软件对患者原始MRI图像进行处理,得出颅内动脉重塑(BAR)评分.根据BAR评分将患者分为颅内大动脉直径缩窄组(58例)、颅内大动脉直径平均组(37例)、颅内大动脉直径扩张组(56例).应用Logistic回归分析颅内动脉直径与认知功能障碍的关系,Pearson相关性分析颅内动脉直径与MoCA总分及MoCA各子项得分的关系.结果 Logistic回归分析提示颅内动脉直径扩张(OR=1.214,95%CI:1.127～1.307,P<0.01)是认知功能障碍的危险因素.颅内动脉直径扩张与MoCA总分(r=-0.306,P<0.001)、视空间与执行功能(r=-0.237,P=0.003)、语言(r=-0.238,P=0.003)、抽象(r=-0.160,P=0.049)、延迟回忆(r=-0.180,P=0.027)、定向(r=-0.163,P=0.046)呈负相关.结论 颅内动脉直径扩张是CSVD患者认知功能障碍的危险因素,颅内动脉直径扩张与MoCA校正后总分、视空间与执行功能、语言、抽象、延迟回忆、定向力呈负相关.
Objective To discuss the possible relation between intracranial artery diameter and cognitive function in patients with cerebral small vessel disease(CSVD),in order to furnish new perspectives for the early recognition,diagnosis,intervention and prognosis of vascular cognitive impairment(VCI)patients.Methods A total of 151 CSVD patients hospitalized in the Second Affiliated Hospital of Zhengzhou University or Xinzheng Public People's Hospital from January 2022 to December 2023 were retrospectively included.Montreal cognitive assessment(MoCA)scale was used to assess the cognitive function and separate each participant into the normal cognitive function group(88 cases)and the cognitive dysfunction group(63 cases).3D-slicer software was used to process the original MRI images of the patients,and the brain artery remodeling(BAR)score was obtained.According to BAR score,the patients were divided into intracranial artery diameter narrowing group(58 cases),intracranial artery diameter average group(37 cases),and intracranial artery diameter expansion group(56 cases).Logistic regression was used to analyze the relationship between intracranial artery diameter and cognitive dysfunction,and Pearson correlation was used to analyze the relationship between intracranial artery diameter and the total score of MoCA and each subitem of MoCA score.Results The result of Logistic analysis showed that intracranial artery dilation(OR=1.214,95%CI:1.127-1.307,P<0.01)were risk factors for cognitive dysfunction.Pearson correlation analysis showed that the intracranial artery dilation has inverse correlation with MoCA overall scores(r=-0.306,P<0.001),visual space and executive function(r=-0.237,P=0.003),language(r=-0.238,P=0.003),abstraction(r=-0.160,P=0.049),delayed recall(r=-0.180,P=0.027),and orientation(r=-0.163,P=0.046).Conclusion Intracranial artery diameter dilation are risk factors for cognitive impairment patients with CSVD.The dilation of intracranial artery diameter has inverse correlation with the overall score of MoCA after adjusted,visual spatial and executive capability,language,abstraction,delayed reminiscence,and orientation.
邢媛媛;路畅;白宏英;姚燕雯;陈静;李彩霞
郑州大学第二附属医院,河南 郑州 450003新郑市公立人民医院,河南 新郑 451150
临床医学
脑小血管病颅内动脉直径认知功能障碍脑萎缩线性测量危险因素
Cerebral small vessel diseaseIntracranial artery diameterCognitive dysfunctionEncephalatrophyLinear measurementRisk factor
《中国实用神经疾病杂志》 2024 (009)
1093-1097 / 5
河南省医学科技攻关计划联合共建项目(编号:LHGJ20230366)
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