中国实用神经疾病杂志2024，Vol.27Issue(9)：1102-1106,5.DOI:10.12083/SYSJ.231863
未破裂颅内动脉瘤患者血清SIRT1和HMGB1的表达及临床意义
Expressions of serum SIRT1 and HMGB1 in patients with unruptured intracranial aneurysm and their clinical significance
摘要
Abstract
Objective To investigate the expressions and clinical significance of silent information regulator factor 2 related enzyme 1(SIRT1)and high mobility group protein B1(HMGB1)in the serum of patients with unruptured intracranial aneurysms.Methods A total of 80 patients with unruptured intracranial aneurysms hospitalized in Jiangyou People's Hospital from January 2020 to January 2021 were selected,another 40 outpatients with physical examination at the same time were selected as the control group.The clinical data and serum SIRT1 and HMGB1 levels were compared between the two groups.The receiver operating characteristic(ROC)curve was used to analyze the value of serum SIRT1 and HMGB1 levels in evaluating the occurrence of unruptured intracranial aneurysms.Results The serum SIRT1 level in patients with unruptured intracranial aneurysms was obviously lower than that in the control group,and the HMGB1 level was obviously higher than that in the control group(P<0.05).The expression levels of serum SIRT1 and HMGB1 in patients with unruptured intracranial aneurysms were significantly correlated with the number and diameter of aneurysms(P<0.05).The ROC curve showed that the AUC of serum SIRT1 and HMGB1 for predicting the incidence of unruptured intracranial aneurysms was 0.944,the sensitivity was 96.15%,and the specificity was 87.04%,which was superior to their respective independent prediction(Zcombination-SIRT1=2.296,P=0.022;Zcombination-HMGB1=2.759,P=0.006).Conclusion There is a significant lower expression of SIRT1 and a significant higher expression of HMGB1 in the serum of patients with unruptured intracranial aneurysms.Both of them are significantly correlated with the clinicopathological characteristics such as the number of aneurysms and the diameter of aneurysms.The combined detection of SIRT1 and HMGB1 has a good predictive value for patients with unruptured intracranial aneurysms.关键词
未破裂颅内动脉瘤/沉默信息调节因子2相关酶1/高迁移率族蛋白B1/血清/病理特征/评估价值Key words
Unruptured intracranial aneurysm/Silent information regulator factor 2 related enzyme 1(SIRT1)/High mobility group protein B1(HMGB1)/Serum/Pathological characteristics/Evaluating value分类
医药卫生引用本文复制引用
张皓,郭锦..未破裂颅内动脉瘤患者血清SIRT1和HMGB1的表达及临床意义[J].中国实用神经疾病杂志,2024,27(9):1102-1106,5.基金项目
四川省医学(青年创新)科研项目资助(编号:Q21104) （青年创新）
广元市科技计划项目(编号:19ZDYF0130) （编号:19ZDYF0130）
