中国实用神经疾病杂志2024，Vol.27Issue(9)：1131-1135,5.DOI:10.12083/SYSJ.240033
连续性血液净化对重型颅脑损伤继发高钠血症患者短期预后的影响
Effect of continuous blood purification on short-term prognosis of patients with hypernatremia secondary to severe craniocerebral injury
摘要
Abstract
Objective To investigate the effect of continuous blood purification(CBP)on short-term prognosis of patients with hypernatremia secondary to severe craniocerebral injury.Methods 98 patients with severe traumatic brain injury admitted to the Affiliated Hospital of Panzhihua University from March 2022 to December 2023 were randomly divided into an experimental group and a control group,with 49 cases in each group,using a random number table method.The control group received routine treatment,and the experimental group received CBP treatment.Blood sodium,osmotic pressure,acute physiological and chronic health scores,liver and kidney function indexes,inflammatory indexes,and hemodynamic indexes were measured,and the prognosis of the two groups was observed.Results After treatment,Serum sodium,plasma osmotic pressure,acute physiological and chronic health scores in the experimental group were lower than those in the control group(145.41±3.26 vs 159.23±4.05,265.34±16.52 vs 291.03±18.41,14.26±4.25 vs 18.33±5.18,respectively,P<0.05).After treatment,urea nitrogen,creatinine,alanine aminotransferase,aspartate aminotransferase in experimental group were lower than those in control group(8.68±2.35 vs 13.26±2.78,140.17±42.86 vs 202.38±65.12,60.58±19.42 vs 84.26±25.37,52.49±16.41 vs 72.92±21.18,respectively,P<0.05).After treatment,interleukin-6,interleukin-1 β,tumor necrosis factor-α in experimental group were lower than those in control group(9.05±2.27 vs 24.76±2.48,3.68±1.19 vs 9.63±3.11,4.35±1.33 vs 10.07±3.15,respectively,P<0.05).After treatment,the mean arterial pressure of the experimental group were higher than those of the control group(92.88±5.62 vs 72.45±6.57,P<0.05),and the central venous pressure in the experimental group was lower than that in the control group(7.12±2.03 vs 11.63±3.47,P<0.05).The survival rate of the experimental group was 79.59%(39/49),and that of the control group was 61.22%(30/49).There was a significant difference between the two groups(χ2=3.967,P=0.046).Conclusion CBP can effectively reduce the disorder of blood sodium and plasma osmotic pressure in patients with hypernatremia secondary to severe craniocerebral injury,improve liver and kidney function,hemodynamics,reduce inflammation,and improve short-term prognosis.关键词
颅脑损伤/高钠血症/连续性血液净化/炎症反应/血浆渗透压紊乱Key words
Craniocerebral injury/Hypernatremia/Continuous blood purification/Inflammation response/Plasma osmolality disorder分类
医药卫生引用本文复制引用
苏利,文利红,唐光旭,李永超,刘杨帆..连续性血液净化对重型颅脑损伤继发高钠血症患者短期预后的影响[J].中国实用神经疾病杂志,2024,27(9):1131-1135,5.基金项目
四川省卫生健康委员会科研课题普及应用项目(编号:20PJ313) （编号:20PJ313）
