湖南中医药大学学报2024，Vol.44Issue(7)：1203-1212,10.DOI:10.3969/j.issn.1674-070X.2024.07.008
鱼腥草挥发性成分"印迹模板"特征研究
Characteristics of the "imprint template" of the volatile components of Houttuynia cordate Thunb.
摘要
Abstract
Objective To elucidate the characteristics of the"imprint template"of volatile components from 144 batches of Houttuynia cordate Thunb.roots from different origins and harvesting time through quantitative analysis,providing an theoretical reference and experimental evidence for the quality evaluation of Chinese medicine imprint.Methods Houttuynia cordate Thunb.from various regions and harvest periods across the country were collected.The volatile oil from the roots was extracted through steam distillation.GC-MS was used to acquire their fingerprint chromatograms and establish a corresponding component database.The"imprint template"of volatile components from each batch was quantitatively characterized to obtain parameters such as molecular connectivity index(MCI),core index(CI),total statistical moment parameters,information entropy,and amount of information.Results Significant differences were observed in the types,numbers,and content of chemical components among different batches.Variations in peak area and information content among the batches were considerable(with RSD values of 68.67%and 79.72%,respectively),and the number of peak also varied significantly(with RSD value of 22.03%).However,information entropy,total statistical first-order moment,and core index(Xvp zeroth-order,Xvp first-order,Xvp second-order)showed minimal changes(with RSD values of 16.17%,13.32%,5.46%,6.38%,and 6.03%,respectively).Conclusion The growth process of raw Chinese medicines centers around the"imprint template",which modifies specific individual components with certain content,and the types and content of those components vary with time and field.The overall performance exhibits patterns of"changed"and"unchanged".The evaluation of imprint quality can offer a novel method for more comprehensive and precise quality control of Chinese medicines.关键词
鱼腥草/挥发油/指纹图谱/物芯指数/总量统计矩/信息熵/信息量/印迹模板Key words
Houttuynia cordata Thunb./volatile oil/fingerprint chromatogram/core index/total statistical moment/infor-mation entropy/amount of information/imprint template分类
医药卫生引用本文复制引用
李文姣,高湘婷,李海英,潘雪,贺福元..鱼腥草挥发性成分"印迹模板"特征研究[J].湖南中医药大学学报,2024,44(7):1203-1212,10.基金项目
国家自然科学基金项目(82274215) （82274215）
湖南省自然科学基金项目(2021JJ30509) （2021JJ30509）
湖南省"国内一流培育学科"药学开放基金项目(2020YX13) （2020YX13）
湖南中医药大学研究生创新项目(2022CX13). （2022CX13）
