湖南中医药大学学报2024，Vol.44Issue(7)：1247-1253,7.DOI:10.3969/j.issn.1674-070X.2024.07.015
基于肾主骨理论探讨肾病与骨质疏松症因果关系的孟德尔随机化分析
Mendelian randomization analysis of the causal relationship between kidney disease and osteoporosis based on the theory of kidney governing bones
摘要
Abstract
Objective To explore the causal relationship between kidney disease and osteoporosis(OP)under the Chinese medicine theory of kidney governing bones.Methods Using the Mendelian randomization approach,single nucleotide polymorphisms(SNPs)related to kidney disease were screened as instrumental variables from the genome-wide association study(GWAS)database.Additionally,the fixed-effect inverse variance weighted method and multiple sensitivity analyses were employed to assess the causal relationship between kidney disease and osteoporosis(OP).Results Five kinds of Mendelian randomization analyses revealed that membranous nephropathy(OR=1.000 6,95%CI:1.000 2～1.000 9,P=0.001 0),chronic glomerulonephritis(OR=1.000 8,95%CI:1.000 1～1.001 5,P=0.038 0),diabetic nephropathy(OR=1.001 0,95%CI:1.000 1～1.002 0,P=0.031 6),and elevated serum creatinine(OR=1.0130,95%CI:1.000 0～1.026 0,P=0.050 8)can significantly increase the risk of OP,while an estimated increase in glomerular filtration rate was associated with a lower risk of OP(OR=0.997 0,95%CI:0.995 3～0.998 6,P=0.000 3).Multiple sensitivity analyses confirmed the robustness of the results,with no notable pleiotropy(MR-Egger intercept P＞0.05)or heterogeneity(Cohran's Q test P＞0.05)identified.Conclusion This study confirms a positive causal relationship between kidney disease and OP,supporting the theory of kidney governing bones.Thus,it provides new evidence for the prevention and treatment of kidney disease-related OP.关键词
骨质疏松症/慢性肾病/肾功能/孟德尔随机化/中医理论Key words
osteoporosis/chronic kidney disease/kidney function/Mendelian randomization/Chinese medicine theory分类
医药卫生引用本文复制引用
匡昱林,王宇凰,欧梁,李洪芳,熊罗节,龚智超,孙绍裘..基于肾主骨理论探讨肾病与骨质疏松症因果关系的孟德尔随机化分析[J].湖南中医药大学学报,2024,44(7):1247-1253,7.基金项目
中国博士后科学基金面上项目(2023M731070) （2023M731070）
湖南省临床医疗技术创新引导项目(2021SK51301) （2021SK51301）
湖南中医药大学研究生创新课题立项项目(2022CX41). （2022CX41）
