机器人外科学杂志（中英文）2024，Vol.5Issue(4)：603-607,5.DOI:10.12180/j.issn.2096-7721.2024.04.020
右美托咪定术中静脉推注剂量对达芬奇机器人经口腔前庭入路甲状腺切除患者瑞芬太尼诱导的输注后痛觉过敏的影响
Effect of intravenous infusion dose of dexmedetomidine during Da Vinci robot-assisted transoral thyroidectomy on remifentanil-induced postoperative hyperalgesia
摘要
Abstract
Objective:To explore the effect of different intravenous infusion doses of dexmedetomidine during Da Vinci robot-assisted transoral thyroidectomy on remifentanil-induced postoperative hyperalgesia.Methods:90 patients who underwent Da Vinci robot-assisted transoral thyroidectomy in the Second Affiliated Hospital of Air Force Medical University from April 2020 to May 2023 were selected and divided into the group A and group B using a random number table,with 45 cases in each group.Patients in the group A were given intravenous infusion of 0.3μg/(kg·h)dexmedetomidine and 0.6μg/(kg·h)to the group B.Hemodynamics,awakening and extubation time,pain degree,and hyperalgesia between the two groups of patients were compared.Results:Inter-and intra-group comparison of heart rate(HR),SpO2 and mean arterial pressure(MAP)at different time points showed significant difference.LSD-t test results showed that HR of the two groups increased at T1 and T2(P<0.05),MAP increased at T1 in group B(P<0.05),and SpO2 in the two groups increased at T1,T2,and T3(P<0.05).However,compared with the group B,the difference in levels of HR,MAP,and SpO2 of group A at T1,T2,and T3 were not statistically significant(P>0.05).Awakening and extubation time in the group A were shorter than those in the group B(P<0.05),and the difference in amount of fentanyl used in the two groups was not statistically significant(P>0.05).Intra-group comparison showed significant difference in the VAS score at different time points,but there was no statistically significant difference in VAS scores between the two groups at 2 h,8 h,12 h and 24 h after surgery(P>0.05).No significant difference in the incidence of pain hypersensitivity was found between the two groups(P>0.05).Conclusion:After remifentanil induced infusion in patients undergoing Da Vinci robot-assisted transoral thyroidectomy,intraoperative intravenous infusion of 0.3 and 0.6 μg/(kg·h)dexmedetomidine dexmedetomidine could stabilize hemodynamics,alleviate pain,and lower pain hypersensitivity,but intravenous infusion of 0.3 μg/(kg·h)dexmedetomidine could shorten patients'recovery and extubation time.关键词
甲状腺切除术/口腔前庭/机器人辅助手术/右美托咪定/痛觉过敏Key words
Thyroidectomy/Oral Vestibule/Robot-assisted Surgery/Dexmedetomidine/Hyperalgesia分类
医药卫生引用本文复制引用
王学佳,姜锐,张进,王宏亮..右美托咪定术中静脉推注剂量对达芬奇机器人经口腔前庭入路甲状腺切除患者瑞芬太尼诱导的输注后痛觉过敏的影响[J].机器人外科学杂志（中英文）,2024,5(4):603-607,5.基金项目
陕西省重点研发计划项目(2021SF-054) Key Research and Development Plan Project of Shaanxi Province(2021SF-054) （2021SF-054）
