临床肝胆病杂志2024，Vol.40Issue(8)：1512-1518,7.DOI:10.12449/JCH240802
中草药相关肝损伤的物质基础及其毒性机制
The material basis and toxic mechanism of herb-induced liver injury
摘要
Abstract
Herb-induced liver injury(HILI)tends to have complex toxic material basis and toxic mechanism,which greatly affects the safety of traditional Chinese medicine.This article summarizes the main toxic components of Chinese herbal medicine causing liver injury and their mechanism of action.The toxic components of Chinese herbal medicine causing liver injury can be classified into two categories of drug-derived and non-drug-derived toxic components.Drug-derived toxic components mainly include alkaloids,terpenoids,anthraquinones,and phenylpropanoids,and their mechanism of action involves oxidative stress,apoptosis and necrosis,CYP450 enzymes,and genotoxicity.Non-drug-derived toxic components mainly include pesticide residues,sulfur dioxide residues,heavy metals,fungi,and plant growth regulators,and their mechanisms involve oxidative stress,apoptosis,metabolic disorders,and CYP450 enzymes.On this basis,this article further proposes the unsolved problems and research difficulties,in order to promote the basic research on the hepatotoxicity of traditional Chinese medicine.关键词
中草药/化学性与药物性肝损伤/物质基础Key words
Drugs,Chinese Herbal/Chemical and Drug Induced Liver Injury/Material Basis引用本文复制引用
刘雪莹,师荟荟,王浩文,杨涛..中草药相关肝损伤的物质基础及其毒性机制[J].临床肝胆病杂志,2024,40(8):1512-1518,7.基金项目
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023060) （zyyzdxk-2023060）
上海市中医药事业发展三年行动计划[ZY(2018-2020)-CCCX-5001] （2018-2020）
上海市科学技术委员会科技创新行动计划医学创新研究专项(20Z21900100) （20Z21900100）
上海市临床重点专科建设项目(shslczdzk01201) High-level Key Discipline Construction Project from State Administration of Traditional Chinese Medicine of China(zyyzdxk-2023060) （shslczdzk01201）
Shanghai TCM Development Three-Year Action Plan Project[ZY(2018-2020)-CCCX-5001] （2018-2020）
Shanghai Science and Technology Innovation Action Plan Medical Innovation Research Special Project(20Z21900100) （20Z21900100）
Shanghai Key Specialty of Traditional Chinese Clinical Medicine(shslczdzk01201) （shslczdzk01201）
