临床肝胆病杂志2024，Vol.40Issue(8)：1585-1590,6.DOI:10.12449/JCH240813
老年人非酒精性脂肪性肝病与骨质疏松的关联分析
Association between nonalcoholic fatty liver disease and osteoporosis in elderly patients
摘要
Abstract
Objective To investigate the association between nonalcoholic fatty liver disease(NAFLD)and osteoporosis in elderly patients.Methods A total of 824 patients,aged≥60 years,who were hospitalized in Department of Gerontology,Peking University People's Hospital,from June 2016 to April 2023 were enrolled,with 398 patients in the osteoporosis group and 426 in the non-osteoporosis group.Related data were collected from all subjects,including general information,blood biochemical parameters,liver ultrasound,and bone mineral density measured by dual-energy X-ray examination.The independent-samples t test was used for comparison of normally distributed continuous data between two groups,and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups;the chi-square test was used for comparison of categorical variables;a binary Logistic regression analysis was used to investigate the independent risk factors for osteoporosis.Results Compared with the non-osteoporosis group,the osteoporosis group had a significantly higher age,a significantly higher proportion of female patients or patients with diabetes,and a significantly lower body mass index(all P<0.05).The osteoporosis group had a significantly higher proportion of patients with NAFLD than the non-osteoporosis group(36.2%vs 24.6%,χ2=12.878,P<0.001).Compared with the non-osteoporosis group,the osteoporosis group had significantly lower levels of hemoglobin,uric acid,and albumin and significantly higher levels of total cholesterol,low-density lipoprotein cholesterol(LDL-C),bone-specific alkaline phosphatase,and tartrate-resistant acid phosphatase(all P<0.05).The binary Logistic regression analysis showed that old age(odd ratio[OR]=1.040,95%confidence interval[CI]:1.015-1.066,P=0.002),female sex(OR=4.089,95%CI:2.607-6.411,P<0.001),NAFLD(OR=1.697,95%CI:1.076-2.678,P=0.023),diabetes(OR=1.509,95%CI:1.008-2.260,P=0.046),and LDL-C(OR=1.431,95%CI:1.010-2.029,P=0.044)were independent risk factors for osteoporosis in elderly patients.Considering the impact of diabetes on the research findings,a subgroup analysis was performed for the patients without diabetes,and the results showed that NAFLD(OR=1.573,95%CI:1.015-2.439,P=0.043)was an independent risk factor for osteoporosis in the elderly patients without diabetes.Conclusion NAFLD,old age,and female sex are independent risk factors for osteoporosis in elderly patients.关键词
非酒精性脂肪性肝病/骨质疏松/老年人Key words
Non-Alcoholic Fatty Liver Disease/Osteoporosis/Aged引用本文复制引用
薛倩,贾春玲,王晶桐..老年人非酒精性脂肪性肝病与骨质疏松的关联分析[J].临床肝胆病杂志,2024,40(8):1585-1590,6.基金项目
国家重大疾病多学科合作诊疗能力建设项目(2020) （2020）
北京大学医学部大健康国际研究院项目(JKCJ202102) National Project of Multidisciplinary Diagnosis and Treatment of Major Diseases(2020) （JKCJ202102）
International Institute of Population Health,Peking University Health Science Center(JKCJ202102) （JKCJ202102）
