临床肝胆病杂志2024，Vol.40Issue(8)：1646-1652,7.DOI:10.12449/JCH240822
间充质干细胞对慢加急性肝衰竭治疗效果的Meta分析
Therapeutic effect of mesenchymal stem cells on acute-on-chronic liver failure:A Meta-analysis
摘要
Abstract
Objective To systematically evaluate the efficacy and safety of mesenchymal stem cells(MSC)in the treatment of acute-on-chronic liver failure(ACLF).Methods This study was conducted according to PRISMA guidelines,with the PROSPERO registration number of CRD42024517851.PubMed,Embase,Wanfang Data,VIP,CNKI,CBM,and the Cochrane Library were searched for randomized controlled trials(RCT)and cohort studies on MSC in the treatment of ACLF published up to November 1,2023,and the articles were screened according to inclusion and exclusion criteria.After data extraction and quality assessment,RevMan 5.3 software was used to perform the Meta-analysis.Results A total of 11 articles involving 803 subjects were included in this meta-analysis.The results showed that for the patients with ACLF,MSC could improve 8-week survival rate(odds ratio[OR]=2.71,95%confidence interval[CI]:1.58-4.67,P=0.000 3),12-week survival rate(OR=2.24,95%CI:1.36-3.69,P=0.001),24-week survival rate(OR=2.09,95%CI:1.37-3.17,P=0.000 6),and 48-week survival rate(OR=2.09,95%CI:1.29-3.40,P=0.003)and reduce 12-week Model for End-Stage Liver Disease(MELD)score(mean difference[MD]=-3.27,95%CI:-6.07 to-0.48,P=0.02)and 24-week MELD score(MD=-2.24,95%CI:-3.16 to-1.33,P<0.000 01);it could also reduce the level of total bilirubin after 4 weeks of treatment(MD=-36.86,95%CI:-48.72 to-25.01,P<0.000 01)and increase 4-week albumin level(MD=2.11,95%CI:0.62-3.61,P=0.006)and 24-week albumin level(MD=3.54,95%CI:2.06-5.02,P<0.000 01).Adverse events were evaluated in 6 studies,with no serious adverse events.Conclusion MSC have a good safety in treatment and can improve the survival rate of patients and enhance liver function to some extent,and therefore,it holds promise for clinical application.关键词
慢加急性肝功能衰竭/间质干细胞/治疗结果/Meta分析Key words
Acute-On-Chronic Liver Failure/Mesenchymal Stem Cells/Treatment Outcome/Meta-Analysis引用本文复制引用
丁航,李小芬,熊艳,李艳艳,陈秀记,王晓霖..间充质干细胞对慢加急性肝衰竭治疗效果的Meta分析[J].临床肝胆病杂志,2024,40(8):1646-1652,7.基金项目
湖北省自然科学基金(2013CFB385) Natural Science Foundation of Hubei Province(2013CFB385) （2013CFB385）
