临床肝胆病杂志2024，Vol.40Issue(8)：1666-1669,4.DOI:10.12449/JCH240825
原发性胆汁性胆管炎-自身免疫性肝炎重叠综合征合并肺隐球菌病1例报告
Primary biliary cholangitis-autoimmune hepatitis overlap syndrome comorbid with pulmonary cryptococcosis:A case report
摘要
Abstract
Patients with overlap syndrome(OS)of autoimmune liver disease may present with more than one biochemical,immunological,histological or cholangiography features of autoimmune liver disease(AILD)and often require a combination of immunosuppressants for treatment.Pulmonary cryptococcosis is a type of invasive pneumomycosis caused by Cryptococcus neoformans or Cryptococcus gattii and has a relatively high incidence rate in immunocompromised patients.This case report presents a patient with OS who was found to have pulmonary cryptococcosis during immunosuppressive therapy and developed abnormal liver function during antifungal treatment.Based on the liver function of the patient,the feasibility of adjusting antifungal agents was assessed,and active treatment strategies for novel cryptococcal infection were developed under the close monitoring of liver function,which helped to avoid the progression of infection.It is suggested that before the initiation of immunosuppressive therapy,systemic foci of infection should be comprehensively evaluated,and suspicious foci of infection should be monitored continuously.关键词
肝炎,自身免疫性/原发性硬化性胆管炎/隐球菌属/肺疾病,真菌性Key words
Hepatitis,Autoimmune/Primary Biliary Cholangitis/Cryptococcus/Lung Diseases,Fungal引用本文复制引用
张明明,刘寰,张冬梅,吴东波,唐红..原发性胆汁性胆管炎-自身免疫性肝炎重叠综合征合并肺隐球菌病1例报告[J].临床肝胆病杂志,2024,40(8):1666-1669,4.基金项目
四川大学华西医院学科卓越发展1·3·5工程项目(ZYGD23030) 1·3·5 Project for Disciplines of Excellent,West China Hospital,Sichuan University(ZYGD23030) （ZYGD23030）
