临床肝胆病杂志2024，Vol.40Issue(8)：1670-1676,7.DOI:10.12449/JCH240826
生物钟调控的线粒体动力学在非酒精性脂肪性肝病中的作用
The role of circadian clock-controlled mitochondrial dynamics in nonalcoholic fatty liver disease
摘要
Abstract
Nonalcoholic fatty liver disease(NAFLD)is a disease closely associated with metabolic abnormalities and is currently one of the most common chronic liver diseases.Mitochondria are highly dynamic organelles involved in a variety of metabolic and bioenergetic pathways in the liver,and they respond to environmental changes in a highly dynamic manner through mitochondrial dynamics.The circadian clock is able to modulate mitochondrial dynamics,making it exhibit rhythmic changes.In case of circadian rhythm disorders,mitochondrial dynamics loses rhythmicity,and mitochondria are unable to respond to changing energy demands in different environments,leading to the development and progression of NAFLD.This article summarizes the important role of circadian clock-controlled mitochondrial dynamics in the etiology of NAFLD.关键词
非酒精性脂肪性肝病/生物钟/线粒体动力学Key words
Non-alcoholic Fatty Liver Disease/Biological Clocks/Mitochondrial Dynamics引用本文复制引用
张策,苗嘉芮,樊旭..生物钟调控的线粒体动力学在非酒精性脂肪性肝病中的作用[J].临床肝胆病杂志,2024,40(8):1670-1676,7.基金项目
辽宁省教育厅基本科研项目(LJKMZ20221307) Basic Research Projects of Education Department of Liaoning Province(LJKMZ20221307) （LJKMZ20221307）
