临床肝胆病杂志2024，Vol.40Issue(8)：1693-1698,6.DOI:10.12449/JCH240830
铁死亡在肝缺血再灌注损伤中的作用
Role of ferroptosis in hepatic ischemia-reperfusion injury
摘要
Abstract
Ferroptosis is a new type of regulatory cell death and is mainly caused by changes in intracellular iron homeostasis due to various inducers,which promotes the occurrence of iron ion-dependent lipid peroxidation,thereby leading to the accumulation of toxic lipid peroxides and finally resulting in cell death.Hepatic ischemia-reperfusion injury is a common and serious complication after liver surgery,with the main mechanisms of anaerobic respiration,mitochondrial injury,oxidative stress response,inflammatory response,calcium overload,and microcirculation dysfunction.This article introduces the concepts and mechanisms of ferroptosis and hepatic ischemia-reperfusion injury and summarizes some related treatment strategies,so as to provide a reference for exploring new treatment methods for hepatic ischemia-reperfusion injury.关键词
铁死亡/再灌注损伤/肝疾病Key words
Ferroptosis/Reperfusion Injury/Liver Diseases引用本文复制引用
梁佳新,徐宝麟,成雨,魏勇..铁死亡在肝缺血再灌注损伤中的作用[J].临床肝胆病杂志,2024,40(8):1693-1698,6.基金项目
山东省中医药科技计划项目(2021M160) Shandong Traditional Chinese Medicine Technology Project(2021M160) （2021M160）
