临床误诊误治2024，Vol.37Issue(14)：74-78,5.DOI:10.3969/j.issn.1002-3429.2024.14.016
清气化痰丸加减联合丙卡特罗治疗痰热蕴肺证支气管哮喘的临床效果及对炎性因子的影响
Clinical Effect of Qingqi Huatan Pill Combined with Procatterol in the Treatment of Bronchial Asthma with Syndrome of Phlegm-heat Obstructing Lung and Its Effect on Inflammatory Factors
摘要
Abstract
Objective To evaluate the clinical effect of Qingqi Huatan pill combined with Procatterol on bronchial asthma with syndrome of phlegm-heat obstructing lung.Methods A total of 130 patients with bronchial asthma with syndrome of phlegm-heat obstructing lung admitted from January 2022 to December 2023,were divided into observation group(n=65)and control group(n=65)according to random number table method.The control group was given Procatterol Hydrochloride granules,and the observation group was supplemented with modified Qingqi Huatan pill on the basis of the control group.Both groups were treated for 14 consecutive days.Clinical efficacy,TCM symptom scores,lung function indexes[forced expiratory volume in the first second(FEV1),FEV1/forced vital capacity(FVC),and peak expiratory flow(PEF)],inflammatory factor indexes[interleukin-6(IL-6),interleukin-8(IL-8),immunoglobulin E(IgE)],immune indexes(CD3+,CD4+,CD8+,CD4+/CD8+)before and after treatment,and the occurrence of adverse drug reactions were observed in the two groups.Results The total effective rate of the observation group was 90.77%,which was higher than that in the control group(73.85%)(P＜0.05).After treatment,the TCM syndrome scores of both groups were decreased compared with those before treatment,which were lower in the observation group than in the control group(P＜0.05,P＜0.01).The levels of FEV1/FVC,FEV1 and PEF,in both groups were significantly improved compared with those before treatment,and the chan-ges in the above indicators were more significant in the observation group(P＜0.05,P＜0.01).After treatment,the levels of IL-6,IL-8 and IgE were all decreased compared with the previous levels,and the changes were more significant in the obser-vation group(P＜0.05,P＜0.01).After treatment,the levels of CD3+,CD4+,and CD4+/CD8+were increased in both groups,while the level of CD8+was decreased;the changes in these indicators in the observation group were more sig-nificant than those in the control group(P＜0.05,P＜0.01).No adverse reactions were observed in each group.Conclu-sion Modified Qingqi Huatan pills combined with Procaterol has good efficacy in the treatment of bronchial asthma patients with syndrome of phlegm-heat obstructing lung.It can significantly improve clinical symptoms,lung function and immune function,and reduce airway inflammatory reactions,with good safety.关键词
支气管哮喘/痰热蕴肺/清气化痰丸/第1秒用力呼气容积/白细胞介素-6/CD3+/药物毒性Key words
Bronchial asthma/Phlegm-heat accumulating lung/Qingqi Huatan pills/Forced expiratory volume in the first second/Interleukin-6/CD3+/Drug toxicity分类
医药卫生引用本文复制引用
观云,武蕾,彭飞飞,张萱..清气化痰丸加减联合丙卡特罗治疗痰热蕴肺证支气管哮喘的临床效果及对炎性因子的影响[J].临床误诊误治,2024,37(14):74-78,5.基金项目
河北省科技厅科研计划项目(192777130D) （192777130D）
河北省中医药管理局科研计划项目(2020052,2020025) （2020052,2020025）
