临床眼科杂志2024，Vol.32Issue(4)：314-319,6.DOI:10.3969/j.issn.1006-8422.2024.04.006
2型糖尿病患者眼表变化及影响因素分析
Analysis of Ocular Surface Changes and Influencing Factors in Patients with Type 2 Diabetes
摘要
Abstract
Objective To explore the changes and influencing factors of ocular surface function in patients with type 2 diabetes.Methods Retrospective case-control study,A total of 61 patients(122eyes)with type 2 diabetes diag-nosed in our hospital from 2022～09 to 2023～09 were collected as observation group,aged(61.44±7.14)years old.The control group consisted of 61 healthy patients(122eyes)aged(64.52±6.93)years old.All subjects were tested for average tear break-up time(ATBUT),tear meniscus height(TMH),and meibomian gland absence score using Keratograph 5M ocular surface comprehensive analyzer.Schirmer 1 test(SIT)was performed using tear secretion filter strips,corneal fluo-rescent stain test(FL)was performed using fluorescein sodium ophthalmic test strips,and subjective scores were obtained using the Ocular Surface Disease Index(OSDI).Record the duration of diabetes and perform glycated hemoglobin(HbA1c)testsin type 2 diabetic patients.Group patients according to their age and HbA1c,and analyze whether there are differences in the above indicators under different grouping conditions.Results The overall comparison between the case group and the control group showed statistically significant differences in ATBUT,TMH,meibomian gland absence score,SIT,FL,and OSDI scores(P<0.05);There were significant differences in ATBUT,SIT,TMH,FL,meibomian gland absence score between type 2 diabetes patients with HbA1c≥7.5%and type 2 diabetes patients with HbA1c<7.5%(P<0.05);Regression analysis using tear break-up time as the dependent variable revealed that glycosylated hemoglobin(P<0.001)and meibomian gland absence score(P=0.014)had an impact on tear break-up time.For every 1%increase in glycosylated hemoglobin value,tear break-up time decreased by 1.635 seconds,while meibomian gland analysis showed a decrease of 0.747 seconds for every 1 unit increase.Conclusions Compared with healthy people of the same age group,patients with type 2 diabetes are more likely to have shorter tear break-up time,lower tear secretion,lower tear me-niscus height,increased meibomian gland absence,and higher corneal fluorescent stain score,and the level of blood glu-cose control is closely related to the tear break-up time.关键词
糖尿病/眼表综合分析仪/糖化血红蛋白/泪液分泌试验/角膜染色/眼表疾病指数Key words
Diabetes/Glycosylatedhemoglobin/Schirmer1 test/Corneal fluorescent stain test/Ocular surface dis-ease index/Ocular surface comprehensive analyzer引用本文复制引用
卢静雯,管一鸣,桂思语,曹凡,蒋正轩..2型糖尿病患者眼表变化及影响因素分析[J].临床眼科杂志,2024,32(4):314-319,6.基金项目
国家自然科学基金(82371080 （）
82171043 （）
82070986) （）
