2型糖尿病患者中不同影响因素下角膜生物力学特性的变化趋势分析OACSTPCD

Objective To analyze the changing trend of corneal hysteresis(CH)and corneal resistance factor(CRF)values under different influencing factors in type 2 diabetes mellitus(T2DM)patients.Methods A total of 650 patients with T2DM visited the First People's Hospital of Ziyang from February 2022 to March 2023 were included.All pa-tients underwent ophthalmoscopy and fundus nuorescein angiography(FFA).Logistic regression analysis was used to evaluate the independent risk factors of gender,age,course of diabetes,hypertension,smoking,drinking,body mass in-dex(BMI),diastolic pressure,fasting blood glucose(FBG),triacylglycerol(TG),total cholesterol(TC),high density lipopretein cholesferel(HDL-C),low density lipoprotein cholesferol(LDL-C)and hemoglobin A1c(HbA1c)related with T2DM.At the same time,according to the course of T2DM,FBG,diabetic retinopathy(DR)stage,HbA1c(%)and other different pathological changes,the corneal hysteresis(CH)and CRF values were measured by the ophthalmic re-sponse analyzer(ORA),and the change trend of their values was analyzed.Results In this study,the course of T2DM,smoking history,BMI,FBG,DR,HbA1c,TC,TG,LDL-C were common risk factors for T2DM,while HDL-C was a pro-tective factor,with statistically significant differences(P<0.05).With the prolongation of T2DM,the increase of FBG,and the accumulation of HbA1C,the values of CH and CRF gradually decreased,especially in HbA1c(%)>12,the val-ues of CH(1.85±0.33)mmHg and CRF(1.28±0.69)mmHg decreased the most.Compared with the Non-DR group,the CH and CRF values gradually decreased in the mild-nonproliferative diabetic retinopathy(NPDR),moderate-NPDR,severe-NPDR,and PDR groups,with the lowest CH and CRF values in the PDR group.Analysis of variance between groups showed statistically significant differences in CH and CRF values(P<0.05).Conclusions In patients with T2DM,early measurement of corneal biomechanical properties by ORA so as to evaluate the change trend of CH and CRF values in different situations will help to identify and prevent diabetic keratopathy as soon as possible.