临床眼科杂志2024，Vol.32Issue(4)：329-332,4.DOI:10.3969/j.issn.1006-8422.2024.04.009
视网膜中央静脉阻塞继发黄斑水肿治疗前后黄斑区视网膜血流参数和脉络膜厚度变化
Changes of retinal blood flow parameters and choroidal thickness in macular area before and after treatment for macular edema secondary to central retinal vein occlusion
摘要
Abstract
Objective The study the changes of macular retinal blood flow parameters and subfoveal choroid thickness(SFCT)in patients with central retinal vein occlusion(CRVO)secondary to macular edema(ME)before and af-ter treatment,and to explore the relationship between SFCT and patients'vision.Methods A total of 29 patients with CRVO secondary macular edema who were treated in Anhui NO.2 Provincial People,s Hospital from Dec.2019 to Aug.2022 were included in the study,and all patients received intraocular injection of Conbercept.Slit lamp,best corrected vi-sual acuity(BCVA),and optical coherence tomography angiography(OCTA)were performed before treatment and at 1 month of treatment,respectively.The changes of SFCT,foveal avascular zone(FAZ),vessel length density(VLD)and perfusion density(PD)before and after treatment were automatically measured by software.Paired t test was used to com-pare the preoperative and postoperative examination results,and Pearson correlation coefficient was used to analyze the re-lationship between SFCT and the visual acuity of patients.Results There were no significant differences in VLD and PD of superficial retinal capillary network in macular area,fovea,para-fovea and total area(P>0.05).Before treatment,the mean SFCT of the affected eye and the contralateral healthy eye were(325.02±64.91)µm and(255.88±50.40)µm,re-spectively,with significant difference(P<0.01,paired t test).At 1 month after injection,the mean SFCT of the affected eye rapidly changed to(260.15±49.36)µm,which was significantly different from that before treatment(P<0.01,paired t-test).BCVA increased from(55.94±10.67)letters before treatment to(62.50±13.55)letters,with significant difference(P<0.05,paired t test).The correlation coefficients between SFCT and BCVA before and after surgery were-0.774 and-0.937,respectively.Conclusions After intravitreal injection of Conbercept,SFCT of ME secondary to CRVO was sig-nificantly decreased and BCVA was significantly increased,indicating a significant correlation between the two.In addi-tion,the treatment of compacciprix had no significant effect on retinal blood flow parameters in macular area.关键词
视网膜中央静脉阻塞/黄斑水肿/视网膜血流参数/中心凹下脉络膜厚度/视力Key words
Central retinal vein occlusion/Macular edema/Retinal blood flow parameters/Subfoveal choroid thickness/Visual acuity引用本文复制引用
王明睿,李晶,王玉丽,夏冉,詹邶,王勇..视网膜中央静脉阻塞继发黄斑水肿治疗前后黄斑区视网膜血流参数和脉络膜厚度变化[J].临床眼科杂志,2024,32(4):329-332,4.基金项目
2023年度安徽省高校科研编制计划项目(2023AH053372) （2023AH053372）
