临床眼科杂志2024，Vol.32Issue(4)：379-383,5.DOI:10.3969/j.issn.1006-8422.2024.04.021
基于高通量测序的眼-鼻区系微生物菌群研究进展
Research progress of ocular and nasopharynx microbial flora based on high throughput sequencing
摘要
Abstract
In recent years,the role of the ocular surface microbiome has attracted more and more attention.The traditional microbial identification mainly focuses on smear,bacterial culture and the other methods of inspection.How-ever,the traditional microbial culture is affected by various factors such as culture conditions,and the positive rate is low.With the launch and implementation of the human metagenome project,high-throughput sequencing technology can define the microbial community to the genus and species level because of its high flux,high sensitivity and specificity,rich infor-mation and low cost,which is helpful to better understand the etiology,diagnosis,treatment and prevention of eye dis-eases,and promote the accurate medical process of eye disease.The eyes and nose are connected in anatomical structure.This paper aims to explore the research progress of microorganisms in the eye and nasopharynx and the possible transmis-sion of eye-nose flora microorganisms,so as to provide a basis for the research of eye-nose related diseases.关键词
眼部/鼻部/微生物/高通量测序Key words
Eye/Nose/Microbiome/High throughput sequencing引用本文复制引用
张馨心,董魁,康志明,孙斌..基于高通量测序的眼-鼻区系微生物菌群研究进展[J].临床眼科杂志,2024,32(4):379-383,5.基金项目
山西省科技厅基础类研究项目(202203021212072) （202203021212072）
山西省卫生健康委科技课题(2022135) （2022135）
山西省眼科医院科研基金(B202301) （B202301）
山西省科技厅基础研究计划项目(自然科学研究面上项目)(20210302123343) （自然科学研究面上项目）
山西省卫生健康委四个一批项目(山西省医学重点科技项目计划)(2021XM46) （山西省医学重点科技项目计划）
