环境与职业医学2024，Vol.41Issue(8)：884-891,8.DOI:10.11836/JEOM24044
血清尿酸在重金属暴露与代谢综合征关系中的中介效应
Mediating effect of serum uric acid on the relationship between heavy metal exposure and metabolic syndrome
摘要
Abstract
[Background]Heavy metal exposure may be associated with the risk of metabolic syndrome(MetS)and serum uric acid.The role of serum uric acid in the relationship between heavy metal exposure and MetS is currently unclear. [Objective]To evaluate the relationships of heavy metal exposure with MetS and serum uric acid,and to quantify the role of serum uric acid in the relationship. [Methods]In 2021,convenience sampling was used to select 571 local adults in Liuzhou,Guangxi.Demographic characteristics,lifestyle habits,and physiological and biochemical indica-tors were collected through questionnaire surveys and physical examinations.Fasting blood and mid-stream morning urine were also collected.The concentrations of 16 heavy metals in urine were measured using inductively coupled plasma mass spectrometry.Least absolute shrinkage and selection operator(LASSO)regression was employed to identify heavy metals associated with MetS.Logistic regression and linear regression models were employed to evaluate the asso-ciation between the selected heavy metals and MetS as well as serum uric acid.Bayesian kernel machine regression(BKMR)model was utilized to assess the impact of combined exposures to multiple metals on the risk of MetS and identify the main effect metals.Generalized structural equation model was used to evaluate po-tential mediating effect of serum uric acid on the relationship between heavy metal exposure and MetS. [Results]The LASSO regression identified a total of 9 heavy metals that were associated with MetS.The logistic regression revealed a positive correlation between zinc and copper in urine and MetS(P trend<0.05),while vanadium showed a negative correlation with MetS(P trend<0.05).Compared to the low concentration groups,the high concentration groups of zinc(OR=2.37,95%CI:1.33,4.20)and copper(OR=2.29,95%CI:1.26,4.18)had an increased risk of MetS,while the high concentration group of vanadium showed a decreased risk of MetS(OR=0.47,95%CI:0.27,0.84).The main effect metals identified by the BKMR model were consistent with the results of logistic re-gression.The linear regression analysis demonstrated an association between urinary zinc and vanadium concentrations and serum uric acid levels(P trend<0.05).Compared to the low concentration group,the high concentration group of zinc showed an increase in serum uric acid level(β=0.07,95%CI:0.03,0.11),while the high concentration group of vanadium showed a decrease in serum uric acid level(β=-0.06,95%CI:-0.09,-0.02).The mediation analysis revealed that serum uric acid played a mediating role in the relationship between urinary zinc and vanadium concentrations and MetS,with mediation proportions of 8.33%and 16.67%,respectively. [Conclusion]Exposure to heavy metals zinc,copper,and vanadium are closely associated with MetS.Zinc and vanadium exposures are correlated with serum uric acid levels,and serum uric acid plays a partial mediating role in the relationship between zinc and vanadium exposures and MetS.关键词
重金属暴露/代谢综合征/血清尿酸/中介效应Key words
heavy metal exposure/metabolic syndrome/serum uric acid/mediating effect分类
医药卫生引用本文复制引用
覃玲巧,赵敏,许琪,陈伊静,刘忠典,何土凤,钟秋安..血清尿酸在重金属暴露与代谢综合征关系中的中介效应[J].环境与职业医学,2024,41(8):884-891,8.基金项目
国家自然科学基金项目(81860570) （81860570）
