环境与职业医学2024，Vol.41Issue(8)：934-940,7.DOI:10.11836/JEOM24029
脂质代谢和脂类营养干预在儿童癌症中的研究进展
A minireview on lipid metabolism and lipid-associated nutritional interventions in childhood cancers
摘要
Abstract
Cancer is a leading cause of mortality in children and results in a significant disease burden.Lipid metabolic reprogramming emerges as a pivotal cancer hallmark,bearing profound implica-tions for understanding tumorigenesis,developing treatment strategies,and improving prog-noses.However,research on lipid metabolism and lipid nutritional interventions related to child-hood cancers is notably limited compared to adult cancers.This review focused on the current understanding of fatty acid,cholesterol,and phospholipid metabolism in childhood cancers and discussed the correlation between major lipid dietary patterns(such as high-fat,ketogenic,and Mediterranean diets)and the development and progression of childhood cancers.This review also highlighted existing research gaps on the mechanisms of lipid metabolism and the effects of major lipid dietary patterns,and warranted improved research depth,experimental design,and sample size.Therefore,we advocate for future epidemiological,basic science,and multidisciplinary re-search in the field of childhood cancers to understand more comprehensively and profoundly the role of lipid nutrition in the prevention and treatment of pediatric cancers.关键词
脂质代谢/儿童癌症/营养干预Key words
lipid metabolism/pediatric cancer/nutritional intervention分类
医药卫生引用本文复制引用
沈嫣然,毕心语,龚阳奕,宋恩名,陶灵..脂质代谢和脂类营养干预在儿童癌症中的研究进展[J].环境与职业医学,2024,41(8):934-940,7.基金项目
国家自然科学基金项目(82304124) （82304124）
