产前双酚S暴露对子代脂质代谢的影响及其作用机制的研究进展OA北大核心CSTPCD

Bisphenols are widely used in the manufacture of polycarbonates and plastics.With the restriction and banning of bisphenol A(BPA),a typical representative of bisphenols,bisphenol S(BPS)has been widely used in the manufacture of various polymers as the main alternative to BPA.Humans are exposed to BPS through a variety of routes,and BPS is detected in food,envi-ronment,and human blood and excreta.Concerns about the safety of BPS have become an im-portant issue,especially for pregnant women and fetuses.The results of several studies support that prenatal exposure to BPS have multiple adverse effects on the offspring.In particular,prenatal BPS exposure may affect maternal and offspring metabolic homeostasis and increase the risk of abnormal lipid metabolism in the offspring.This paper summarized the results of studies on BPS exposure and abnormal lipid metabolism.In addition,this review explored potential mechanisms of BPS,including its possible influence on lipid metabolism through interference with hormone receptors,activation of the nuclear receptor peroxisome proliferator-activated receptor γ(PPARγ),induction of oxidative stress and inflammatory states,and epigenetic effects.These findings emphasized the importance of more in-depth research on BPS and its potential effects to better understand its impact on human health and to provide a basis for developing appropriate public health measures to reduce the risk of BPS exposure.