炎症性肠病伴皮肤表现的临床与病理分析OA

Objective To analyze the clinical and histopathological features of skin manifesta-tions of inflammatory bowel disease(IBD)in order to provide guidance for clinical diagnosis.Meth-ods Clinical and pathological characteristics of 2 patients with IBD were retrospectively analyzed.Results One patient had Crohn's disease manifested by perianal erythema and ulcers,and histopa-thology showed non-caseous and non-infectious granuloma in the dermis.Treatment with Ustekinum-ab decreased the ulcerative area.In another case of ulcerative colitis with extraintestinal manifesta-tions,erythemas and nodules were all over the body,and ulcers were on the lower legs and but-tocks.Histopathology showed dermal neutrophil infiltration.The skin lesions partially subsided after the treatment with Infliximab.Conclusions IBD with cutaneous manifestations has different his-topathological characteristics,and clinicians should make the diagnosis based on both clinical mani-festations and histopathological features in order to avoid misdiagnosis and missed diagnosis.