皮肤性病诊疗学杂志2024，Vol.31Issue(8)：560-566,7.DOI:10.3969/j.issn.1674-8468.2024.08.010
度普利尤单抗治疗大疱性类天疱疮的研究进展
Research progress on the treatment of bullous pemphigoid with Dupilumab
摘要
Abstract
In recent years,there have been many reports on the use of Dupilumab in the treat-ment of bullous pemphigoid.Dupilumab specifically binds to the subunit alpha of interleukin 4 re-ceptor(IL-4Rα),blocking the signal transduction of interleukin(IL)-4 and IL-13,inhibiting the proliferation of B cells,reducing the recruitment of eosinophils,and suppressing the function of Th2-related chemotactic factors,thereby improving skin lesions and itching of patients.This arti-cle reviews the potential mechanisms,clinical efficacy,and adverse reactions of Dupilumab in the treatment of bullous pemphigoid.关键词
大疱性类天疱疮/治疗/度普利尤单抗Key words
bullous pemphigoid/treatment/Dupilumab引用本文复制引用
罗晓佳,姜福琼,张耀中,高健..度普利尤单抗治疗大疱性类天疱疮的研究进展[J].皮肤性病诊疗学杂志,2024,31(8):560-566,7.基金项目
云南省科技厅科技计划项目(202301AY070001-248) （202301AY070001-248）
