岭南现代临床外科2024，Vol.24Issue(3)：150-156,7.DOI:10.3969/j.issn.1009-976X.2024.03.002
基于黄金角径向并行采集技术的MRI动态增强评估肝纤维化的研究
Dynamic contrast-enhanced MRI based on GRASP technique for the assessment of liver fibrosis
摘要
Abstract
Objective To investigate the value of dynamic contrast-enhanced MRI(DCE-MRI)based on golden-angle radial sparse parallel(GRASP)acquisition technique in assessing the degree of liver fibrosis staging.Methods This was a prospective enrollment of patients who underwent resection for localized liver lesions at Sun Yat-sen Memorial Hospital,Sun Yat-sen University,between September 2022 and December 2023,with subsequent assessment of fibrosis staging in the peritumoral liver tissue.All patients underwent preoperative DCE-MRI examination using the GRASP technique.Quantitative DCE-MRI parameters including arterial flow(Fa),portal venous flow(Fv),total blood flow(Ftotal),arterial flow fraction(AF),mean extracellular transit time(MTT),and extracellular volume(ECV)were mea-sured in all patients.Parameter comparisons for different liver fibrosis stages were performed using t-tests.Spearman's rank correlation test method was used to assess the correlation between each DCE parameter and the liver fibrosis staging.The efficacy of the model was evaluated using Receiver Operating Character-istic(ROC)curve analysis.Results DCE-MRI parameters were analyzed in 76 participants(64 males).Compared to non-late(S≤2)patients,late patients(S≥3)showed a decrease in Fv(125.1 vs.104.26 ml/100 ml/min,P=0.013),an increase in AF(45.24%vs.51.89%,P=0.013),and an increase in ECV(35.46 vs.40.44 ml/100 ml,P<0.001).Across fibrosis stages,Fv(r=-0.326,P=0.004)decreased with increasing stages,and AF(r=0.317,P=0.005)and ECV(r=0.569,P<0.001)increased with increasing stages.The cut-off value for Fv was 145.13 mL/100 mL/min with an AUC of 0.651(95%CI:0.524～0.778,P=0.026),and the cut-off value for AF was 42.97%with an AUC of 0.652(95%CI:0.521～0.782,P=0.025),and a cut-off value of 37.72 mL/100 mL for ECV,with an AUC of 0.776(95%CI:0.664～0.888,P<0.001).Conclusion Quantitative GRASP-based DCE-MRI parameters can be employed to diagnose and stage the liver fibrosis.关键词
磁共振成像/动态对比增强/肝纤维化Key words
magnetic resonance imaging/dynamic contrast enhancement/liver fibrosis分类
医药卫生引用本文复制引用
曾坤杰,段小慧,颜卓恒,曾佳乐,赖朝奇,苏赟..基于黄金角径向并行采集技术的MRI动态增强评估肝纤维化的研究[J].岭南现代临床外科,2024,24(3):150-156,7.基金项目
广东省医学科学技术研究基金(A2023104) （A2023104）
