老年医学与保健2024，Vol.30Issue(4)：920-924,5.
瘦素受体基因rs1137101位点多态性与老年人群代谢相关脂肪性肝病发生风险的关系研究
A study on relationship between polymorphism of leptin receptor gene rs1137101 locus and risk of metabolic-associated fatty liver disease in elderly population
摘要
Abstract
Objective To investigate the relationship between polymorphism of leptin receptor gene rs1 137101 locus and risk of metabolic-associated fatty liver disease(MAFLD)in the elderly.Methods From January 2020 to September 2021,1 019 elderly volunteers were recruited from Mentougou Community in Beijing for physical examination,including 569 ones in the MAFLD group and 450 ones in the non-MAFLD group.Their clinical data were recorded,and the genotype of LEPR-rs1137101 polymorphism was detected by gene chip.Logistic regression analysis was used to evaluate the relationship be-tween gene polymorphism and the occurrence of MAFLD.Results Among the elderly population,rs1 137101 G＞A polymor-phism was more common in the MAFLD group than that in the non-MAFLD group(36.91％vs 24.00％,P＜0.05).The LEPR-rs1 137101 A allele was associated with an increased risk of MAFLD(OR=1.695,95％CI:1.140-2.520,P＜0.05).Conclusion LEPR-rs1 137101 A gene may be related to the occurrence of MAFLD in the elderly population.关键词
老年/代谢相关脂肪性肝病/瘦素受体/基因多态性Key words
elderly/metabolic associated fatty liver disease/leptin receptor/gene polymorphism引用本文复制引用
韦新焕,马丽霞,郭海清,赵锦涵,曹振环,杜晓菲,仇丽霞,张晶..瘦素受体基因rs1137101位点多态性与老年人群代谢相关脂肪性肝病发生风险的关系研究[J].老年医学与保健,2024,30(4):920-924,5.基金项目
北京市属医院科研培育计划项目(PX2024061) （PX2024061）
北京市卫生健康委员会高层次公共卫生技术人才建设项目(03-23). （03-23）
