血浆长链非编码RNA SOX2-OT在老年慢性阻塞性肺疾病急性加重相关性肺动脉高压患者中的临床意义OACSTPCD
Clinical significance of plasma long non-coding RNA SOX2-OT in elderly patients with AECOPD-related acute pulmonary hy-pertension
目的 检测血浆长链非编码RNA SOX2-OT在老年慢性阻塞性肺疾病急性加重(AECOPD)相关性肺动脉高压(PH)患者血浆中的表达水平,探讨其潜在的临床应用价值.方法 前瞻性队列研究,纳入120例确诊为AECOPD的老年患者,根据肺动脉收缩压(PASP)分为2组:A组(AECOPD组,60例)和B组(AECOPD相关PH组,60例).在入院时及入院后10 d,评估并比较2组血浆长链非编码RNA SOX2-OT水平、肺动脉收缩压(PASP)、炎症标志物血浆IL-6和IL-8水平、心脏生物标志物血浆NT-ProBNP水平、动脉血气指标值、肺功能指标值、6分钟步行距离测试结果.采用描述性统计分析2组的基线特征,使用t检验或非参数检验比较2组间的差异.并进行相关性分析以评估SOX2-OT与其他指标的关系.结果 在入院时及入院后10 d,2组PASP、血浆长链非编码RNA SOX2-OT水平、血浆IL-6水平、血浆IL-8水平、血浆NT-ProBNP水平、动脉血气指标(pH值、PaO2、PaCO2)值、肺功能指标(FEV1％、DLCO)值、6分钟步行距离差异均有统计学意义(均P＜0.05).对B组患者从入院到入院后10 d的指标变化进行比较,发现PASP值、血浆SOX2-OT水平、炎症标志物水平、心脏生物标志物水平、动脉血气指标值、肺功能指标值、6分钟步行距离均显示出时间效应(均P＜0.05).在A组和B组中,血浆长链非编码RNA SOX2-OT水平与PASP值、血浆IL-6水平、血浆IL-8水平、血浆NT-ProBNP水平、PaCO2值显示出显著的正相关性(均P＜0.05),而与pH值、PaO2值、FEV1％值、DLCO值、6分钟步行距离呈现出显著的负相关性(均P＜0.05).结论 合并PH的AECOPD老年患者血浆长链非编码RNA SOX2-OT水平明显高于不合并PH的AECOPD老年患者;AECOPD相关PH患者经过控制感染、纠正呼吸衰竭等治疗后,随着肺动脉压力下降,血浆长链非编码RNA SOX2-OT水平明显下降.
Objective To detect the expression level of plasma long non-coding RNA SOX2-OT in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)-related pulmonary hypertension(PH),and explore its potential clinical application value.Methods A prospective cohort study included 120 elderly patients diagnosed with AECO-PD.According to their pulmonary artery systolic pressure(PASP),they were divided into two groups:group A(AECOPD group,60 cases)and group B(AECOPD+PH group,60 cases).At admission and 10 days after admission,the levels of plas-ma long non-coding RNA SOX2-OT,inflammation markers(plasma IL-6 and IL-8)and cardiac biomarker(plasma NT-ProB-NP),as well as PASP,arterial blood gas indexes,lung function indexes,and 6-minute walking distance test results were eval-uated and compared between the two groups.Descriptive statistics were used to analyze the baseline characteristics of the two groups,and t-test or nonparametric test was used to compare the differences between the two groups.Correlation analysis was performed to evaluate the relationship between SOX2-OT and other indicators.Results At admission and 10 days after admis-sion,there were statistically significant differences in the levels of plasma long non-coding RNA SOX2-OT,IL-6,IL-8 and plasma NT-ProBNP,and PASP,arterial blood gas indicators(pH,PaO2,PaCO2)values,lung function indicators(FEV1％,DLCO)values,and 6-minute walking distance between the two groups(all P＜0.05).The index changes of the group B from admission to 10 days after admission were compared,and it was found that PASP value,plasma SOX2-OT level,inflammation marker level,cardiac biomarker level,arterial blood gas index value,lung function index value and 6-minute walking distance all showed time effects(all P＜0.05).In group A and group B,the level of plasma long non-coding RNA SOX2-OT was sig-nificantly positively correlated with PASP value,plasma IL-6 level,plasma IL-8 level,plasma NT-ProBNP level and PaCO2 value(all P＜0.05),and negatively correlated with pH value,PaO2 value,FEV1％value,DLCO value and 6-minute walking distance(all P＜0.05).Conclusion The level of plasma long non-coding RNA SOX2-OT in AECOPD patients with AECO-PD-related PH is significantly higher than that in AECOPD patients without AECOPD-related PH.After treatment such as infec-tion control and correction of respiratory failure,the level of plasma long non-coding RNA SOX2-OT decreased significantly in patients with AECOPD-related PH as pulmonary artery pressure decreased.
张诚实;陈荣荣;秦二云;张青;刘明;冯契靓;赵云峰
上海市浦东新区浦南医院呼吸内科,上海 200125
老年慢性阻塞性肺疾病急性加重肺动脉高压长链非编码RNASOX2-OT
elderlyacute exacerbation of chronic obstructive pulmonary diseasepulmonary hypertensionlong non-coding RNASOX2-OT
《老年医学与保健》 2024 (004)
985-989 / 5
上海市浦东新区卫生系统重点学科建设资助(PWZxk2022-24);上海市浦东新区卫生系统临床特色学科建设资助(PWYts2021-04)
评论