老年医学与保健2024，Vol.30Issue(4)：985-989,5.
血浆长链非编码RNA SOX2-OT在老年慢性阻塞性肺疾病急性加重相关性肺动脉高压患者中的临床意义
Clinical significance of plasma long non-coding RNA SOX2-OT in elderly patients with AECOPD-related acute pulmonary hy-pertension
摘要
Abstract
Objective To detect the expression level of plasma long non-coding RNA SOX2-OT in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)-related pulmonary hypertension(PH),and explore its potential clinical application value.Methods A prospective cohort study included 120 elderly patients diagnosed with AECO-PD.According to their pulmonary artery systolic pressure(PASP),they were divided into two groups:group A(AECOPD group,60 cases)and group B(AECOPD+PH group,60 cases).At admission and 10 days after admission,the levels of plas-ma long non-coding RNA SOX2-OT,inflammation markers(plasma IL-6 and IL-8)and cardiac biomarker(plasma NT-ProB-NP),as well as PASP,arterial blood gas indexes,lung function indexes,and 6-minute walking distance test results were eval-uated and compared between the two groups.Descriptive statistics were used to analyze the baseline characteristics of the two groups,and t-test or nonparametric test was used to compare the differences between the two groups.Correlation analysis was performed to evaluate the relationship between SOX2-OT and other indicators.Results At admission and 10 days after admis-sion,there were statistically significant differences in the levels of plasma long non-coding RNA SOX2-OT,IL-6,IL-8 and plasma NT-ProBNP,and PASP,arterial blood gas indicators(pH,PaO2,PaCO2)values,lung function indicators(FEV1％,DLCO)values,and 6-minute walking distance between the two groups(all P＜0.05).The index changes of the group B from admission to 10 days after admission were compared,and it was found that PASP value,plasma SOX2-OT level,inflammation marker level,cardiac biomarker level,arterial blood gas index value,lung function index value and 6-minute walking distance all showed time effects(all P＜0.05).In group A and group B,the level of plasma long non-coding RNA SOX2-OT was sig-nificantly positively correlated with PASP value,plasma IL-6 level,plasma IL-8 level,plasma NT-ProBNP level and PaCO2 value(all P＜0.05),and negatively correlated with pH value,PaO2 value,FEV1％value,DLCO value and 6-minute walking distance(all P＜0.05).Conclusion The level of plasma long non-coding RNA SOX2-OT in AECOPD patients with AECO-PD-related PH is significantly higher than that in AECOPD patients without AECOPD-related PH.After treatment such as infec-tion control and correction of respiratory failure,the level of plasma long non-coding RNA SOX2-OT decreased significantly in patients with AECOPD-related PH as pulmonary artery pressure decreased.关键词
老年/慢性阻塞性肺疾病急性加重/肺动脉高压/长链非编码RNA/SOX2-OTKey words
elderly/acute exacerbation of chronic obstructive pulmonary disease/pulmonary hypertension/long non-coding RNA/SOX2-OT引用本文复制引用
张诚实,陈荣荣,秦二云,张青,刘明,冯契靓,赵云峰..血浆长链非编码RNA SOX2-OT在老年慢性阻塞性肺疾病急性加重相关性肺动脉高压患者中的临床意义[J].老年医学与保健,2024,30(4):985-989,5.基金项目
上海市浦东新区卫生系统重点学科建设资助(PWZxk2022-24) （PWZxk2022-24）
上海市浦东新区卫生系统临床特色学科建设资助(PWYts2021-04) （PWYts2021-04）
